Mito-extra

Mito-extra may be available in the countries listed below.

Ingredient matches for Mito-extra

Mitomycin

Mitomycin is reported as an ingredient of Mito-extra in the following countries:

• Germany

International Drug Name Search

Divista

Pronunciation: FOE-lik AS-id/VYE-ta-min/oh-MAY-ga 3 FA-tee AS-ids/BYE-oh-tin/KROE-mee-uhm
Generic Name: Folic Acid/Vitamin B6/Vitamin B12/Omega-3 Fatty Acids/Biotin/Chromium
Brand Name: Divista

Divista is used for:

Supplementing the diet in patients who have or are at risk of developing type 2 diabetes. It should be used along with other treatments for type 2 diabetes. It may also be used for other conditions as determined by your doctor.

Divista is a folic acid, vitamin, omega-3 fatty acid, and mineral combination. It works by lowering blood sugar by making the cells of the body more sensitive to the action of insulin. It also provides vitamins and other supplements to meet nutritional requirements.

Do NOT use Divista if:

• you are allergic to any ingredient in Divista or to fish or fish oil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Divista:

Some medical conditions may interact with Divista. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you take large doses of vitamins (megadoses or multivitamin therapy)


• if you have certain types of anemia (eg, megaloblastic anemia, pernicious anemia) or bleeding problems

Some MEDICINES MAY INTERACT with Divista. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because they may increase the risk of bleeding


• Carbamazepine or phenobarbital because they may decrease Divista's effectiveness


• Hydantoins (eg, phenytoin) because their effectiveness may be decreased by Divista

Ask your health care provider if Divista may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Divista:

Use Divista as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• If you take antacids, check with your doctor or pharmacist about how you should take them with Divista.


• Take Divista on a regular schedule to get the most benefit from it. Taking Divista at the same time each day will help you remember to take it.


• If you miss a dose of Divista, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Divista.

Important safety information:

• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Do not take large doses of vitamins (megadoses or megavitamin therapy) while taking Divista unless directed by your doctor.


• Divista has many vitamins and supplements (chromium, biotin, vitamin B₆, vitamin B₁₂, folic acid, omega-3 fatty acids) in it. Before you start any new medicine, check the label to see if it has the same vitamins in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Divista should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Divista while you are pregnant. If you are or will be breast-feeding while you use Divista, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Divista:

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Divista side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Divista:

Store Divista at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Divista out of the reach of children and away from pets.

General information:

• If you have any questions about Divista, please talk with your doctor, pharmacist, or other health care provider.


• Divista is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Divista. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Divista resources

• Divista Side Effects (in more detail)
• Divista Use in Pregnancy & Breastfeeding
• Divista Drug Interactions
• Divista Support Group
• 0 Reviews for Divista - Add your own review/rating

• Divista Prescribing Information (FDA)


• Animi-3 with Vitamin D Prescribing Information (FDA)


• Fish Oil Consumer Overview


• Lovaza Prescribing Information (FDA)


• Lovaza Advanced Consumer (Micromedex) - Includes Dosage Information


• Mi-Omega NF Prescribing Information (FDA)


• Omacor Prescribing Information (FDA)


• Omacor Consumer Overview


• Omacor Monograph (AHFS DI)

Compare Divista with other medications

• ADHD
• Dietary Supplementation
• Hypertriglyceridemia

Sedivet

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Sedivet

Romifidine

Romifidine is reported as an ingredient of Sedivet in the following countries:

• Australia


• Ireland


• Portugal


• United Kingdom

Romifidine hydrochloride (a derivative of Romifidine) is reported as an ingredient of Sedivet in the following countries:

• Belgium


• France


• Germany


• Italy


• Luxembourg


• Netherlands


• New Zealand


• Norway


• South Africa


• Sweden


• Switzerland


• United States

International Drug Name Search

ASA MK

ASA MK may be available in the countries listed below.

Ingredient matches for ASA MK

Aspirin

Acetylsalicylic Acid is reported as an ingredient of ASA MK in the following countries:

• Colombia

International Drug Name Search

Pirazinamida

Pirazinamida may be available in the countries listed below.

Ingredient matches for Pirazinamida

Pyrazinamide

Pyrazinamide is reported as an ingredient of Pirazinamida in the following countries:

• Chile


• Peru


• Romania

International Drug Name Search

Fluoropos

Fluoropos may be available in the countries listed below.

Ingredient matches for Fluoropos

Fluorometholone

Fluorometholone is reported as an ingredient of Fluoropos in the following countries:

• Czech Republic


• Germany


• Turkey

International Drug Name Search

Thalidomide

In the US, Thalidomide (thalidomide systemic) is a member of the following drug classes: leprostatics, miscellaneous antineoplastics, other immunosuppressants and is used to treat Leprosy - Erythema Nodosum Leprosum and Multiple Myeloma.

US matches:

• Thalidomide

UK matches:

• Thalidomide Celgene 50 mg Hard Capsules (SPC)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

L04AX02

CAS registry number (Chemical Abstracts Service)

0000050-35-1

Chemical Formula

C13-H10-N2-O4

Molecular Weight

258

Therapeutic Categories

Dermatological agent

Immunosuppressant

Antileprotic agent

Chemical Names

(RS)-N-(2,6-Dioxo-3-piperidyl)phthalimid (IUPAC)

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-

N-(2,6-Dioxo-3-piperidyl)phthalimide (WHO)

α-Phthalimidoglutarimide (WHO)

Phthalimide, N-(2,6-dioxo-3-piperidinyl)-

Foreign Names

• Thalidomidum (Latin)
• Thalidomid (German)
• Thalidomide (French)
• Talidomida (Spanish)

Generic Names

• Thalidomide (OS: DCIT, DCF, USAN, BAN)
• 5-22-13-00224 (IS: Beilstein)
• AI3-50606 (IS)
• alpha-Phtahlimidoglutarimide (IS)
• BRN 0030233 (IS)
• Contergan (IS)
• E-217 (IS)
• HSDB 3586 (IS)
• K 17 (IS)
• Kevadon (IS)
• NSC 527179 (IS)
• NSC 66847 (IS)
• Sauramide (IS)
• Thalidomide (PH: USP 32)

Brand Names

• Inmunoprin
  Asofarma, Mexico; Tecnofarma, Chile; Tecnofarma, Colombia



• Talizer
  Serral, Mexico



• Thado
  TTY Biopharm, Taiwan



• Thaled
  Fujimoto Seiyaku, Japan



• Thalidomide Celgene
  Celgene, Austria; Celgene, Germany; Celgene, Sweden



• Thalidomide Pharmion
  Celgene, United Kingdom; Celgene, Ireland; Douglas, New Zealand; Key Oncologics, South Africa; Pharmion, Austria; Pharmion, Australia; Pharmion, Denmark; Pharmion, Israel; Pharmion, Norway



• Thalidomide
  Er-Kim, Turkey; Health Support Ltd, New Zealand



• Thalix
  Dabur, India



• Thalomid
  Celgene, United States

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IUPAC	International Union of Pure and Applied Chemistry
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
SPC	Summary of Product Characteristics (UK)
USAN	United States Adopted Name
WHO	World Health Organization

Click for further information on drug naming conventions and International Nonproprietary Names.

RhinoFlex

Generic Name: acetaminophen and phenyltoloxamine (a seet a MIN oh fen and FEN il toe LOX a meen)

Brand Names: Aceta-Gesic, Acuflex, Alpain, Apagesic, BeFlex, BP Poly-650, Dologesic, Flextra-650, Flextra-DS, Hyflex-650, Hyflex-DS, Lagesic, Major-gesic, Percogesic, Phenagesic, Phenylgesic, Q Flex, Relagesic, RhinoFlex, RhinoFlex 650, Staflex, Vistra, Vitoxapap, Zgesic

What is RhinoFlex (acetaminophen and phenyltoloxamine)?

Acetaminophen is a pain reliever and a fever reducer.

Phenyltoloxamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Acetaminophen and phenyltoloxamine is used to treat runny nose, sneezing, and pain or fever caused by the common cold, flu, or seasonal allergies.

Acetaminophen and phenyltoloxamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about RhinoFlex (acetaminophen and phenyltoloxamine)?

Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have liver or kidney disease, diabetes, glaucoma, urination problems, an enlarged prostate, heart disease, high blood pressure, a stomach ulcer, or an overactive thyroid.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

What should I discuss with my healthcare provider before taking RhinoFlex (acetaminophen and phenyltoloxamine)?

You should not take this medication if you are allergic to acetaminophen or phenyltoloxamine. Do not take this medication without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not use acetaminophen and phenyltoloxamine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

• liver disease or a history of alcoholism;


• 
  

  kidney disease;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  urination problems;

  
  


• 
  

  an enlarged prostate;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  a stomach ulcer; or

  
  


• 
  

  an overactive thyroid.

  
  

It is not known whether acetaminophen and phenyltoloxamine is harmful to an unborn baby. Do not take this medication without telling your doctor if you are pregnant. Acetaminophen and phenyltoloxamine can pass into breast milk and may harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby.

How should I take RhinoFlex (acetaminophen and phenyltoloxamine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up.

One tablet of this medicine may contain up to 650 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Call your doctor if your symptoms do not improve, or if you have a fever for longer than 3 days.

This medication can cause unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cold or allergy medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include feeling very restless, extreme drowsiness, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking RhinoFlex (acetaminophen and phenyltoloxamine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid becoming overheated or dehydrated during exercise and in hot weather. Phenyltoloxamine can decrease sweating and you may be more prone to heat stroke.

RhinoFlex (acetaminophen and phenyltoloxamine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay colored stools, jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms.

  
  

Less serious side effects may include:

• 
  

  dizziness, drowsiness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  mild stomach pain, constipation; or

  
  


• 
  

  problems with memory or concentration.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect RhinoFlex (acetaminophen and phenyltoloxamine)?

Before using this medicine, tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by phenyltoloxamine.

There may be other drugs that can interact with acetaminophen and phenyltoloxamine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More RhinoFlex resources

• RhinoFlex Side Effects (in more detail)
• RhinoFlex Use in Pregnancy & Breastfeeding
• RhinoFlex Drug Interactions
• RhinoFlex Support Group
• 0 Reviews for RhinoFlex - Add your own review/rating

• Acuflex MedFacts Consumer Leaflet (Wolters Kluwer)


• Acuflex Consumer Overview


• Lagesic Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Percogesic Consumer Overview

Compare RhinoFlex with other medications

• Cold Symptoms
• Headache
• Influenza
• Pain

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and phenyltoloxamine.

See also: RhinoFlex side effects (in more detail)

Xyvion

Xyvion may be available in the countries listed below.

Ingredient matches for Xyvion

Tibolone

Tibolone is reported as an ingredient of Xyvion in the following countries:

• Australia

International Drug Name Search

Angichromen

Angichromen may be available in the countries listed below.

Ingredient matches for Angichromen

Trapidil

Trapidil is reported as an ingredient of Angichromen in the following countries:

• Japan

International Drug Name Search

Noxibel

Noxibel may be available in the countries listed below.

Ingredient matches for Noxibel

Mirtazapine

Mirtazapine is reported as an ingredient of Noxibel in the following countries:

• Argentina


• Ecuador

International Drug Name Search

amphetamine and dextroamphetamine

am-FET-a-meen a-SPAR-tate, am-FET-a-meen SUL-fate, dex-troe-am-FET-a-meen SAK-a-rate, dex-troe-am-FET-a-meen SUL-fate

Oral route(Tablet;Capsule, Extended Release)

Amphetamines have a high potential for abuse, and administration for prolonged periods of time may lead to drug dependence and must be avoided. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse events .

Commonly used brand name(s)

In the U.S.

• Adderall


• Adderall XR

Available Dosage Forms:

• Tablet


• Capsule, Extended Release

Therapeutic Class: CNS Stimulant

Chemical Class: Amphetamine

Uses For amphetamine and dextroamphetamine

Amphetamine and dextroamphetamine combination belongs to the group of medicines called central nervous system (CNS) stimulants. It is used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or sudden attacks of deep sleep) .

Amphetamine and dextroamphetamine combination increases attention and decreases restlessness in patients who are overactive, cannot concentrate for very long or are easily distracted, and have unstable emotions. It is also used as part of a total treatment program that also includes social, educational, and psychological treatment .

Amphetamine and dextroamphetamine combination may also be used for other conditions as determined by your doctor .

amphetamine and dextroamphetamine is available only with a doctor's prescription. Prescriptions cannot be refilled. A new prescription must be obtained from your doctor each time you or your child needs amphetamine and dextroamphetamine .

Before Using amphetamine and dextroamphetamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amphetamine and dextroamphetamine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to amphetamine and dextroamphetamine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amphetamine and dextroamphetamine combination in children with attention-deficit hyperactivity disorder below 3 years of age. Safety and efficacy have not been established .

Geriatric

Appropriate studies on the relationship of age to the effects of amphetamine and dextroamphetamine combination have not been performed in the geriatric population .

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using amphetamine and dextroamphetamine.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking amphetamine and dextroamphetamine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using amphetamine and dextroamphetamine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Clorgyline


• Furazolidone


• Iproniazid


• Isocarboxazid


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Procarbazine


• Rasagiline


• Selegiline


• Sibutramine


• Toloxatone


• Tranylcypromine

Using amphetamine and dextroamphetamine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Chlorpromazine


• Citalopram


• Furazolidone


• Venlafaxine

Using amphetamine and dextroamphetamine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Guanethidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of amphetamine and dextroamphetamine. Make sure you tell your doctor if you have any other medical problems, especially:

• Agitation, anxiety, or tension or


• Arteriosclerosis (hardening of the arteries), severe or


• Drug abuse or dependence, history of or


• Glaucoma or


• Heart disease or


• High blood pressure, moderate to severe or


• Overactive thyroid—amphetamine and dextroamphetamine should not be used in patients with these conditions .

• Heart problems or defects or


• High blood pressure, mild or


• Mental illness (e.g., aggressive behavior, hostility, psychosis, mania, family history of suicide, bipolar illness, depression) or


• Seizures, history of or


• Thyroid problems—Use with caution. Serious side effects may occur .

• Tourette's syndrome, history of or other tics—Children and their families should be checked by their doctor for this condition before taking amphetamine and dextroamphetamine .

Proper Use of amphetamine and dextroamphetamine

Take amphetamine and dextroamphetamine only as directed by your doctor. Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence) .

If you think amphetamine and dextroamphetamine is not working properly after you have taken it for several weeks, do not increase the dose. Instead, check with your doctor .

amphetamine and dextroamphetamine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions .

Swallow the extended-release capsule whole with water or other liquids. If you cannot swallow the extended-release capsule, you may open it and sprinkle the medicine into a small amount of applesauce. Stir this mixture well and swallow it right away without chewing. Do not store this mixture for future use. Do not crush or chew the medicine inside the capsule .

You may take the extended-release capsule with or without food .

Dosing

The dose of amphetamine and dextroamphetamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of amphetamine and dextroamphetamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For attention-deficit hyperactivity disorder:
    
    • Adults and children 6 years of age and older—At first, 5 milligrams (mg) one to two times a day. Your doctor may increase your dose if needed.
    
    
    • Children 3 to 5 years of age—At first, 2.5 mg daily. Your doctor may increase your dose if needed.
    
    
    • Children younger than 3 years of age—Use is not recommended .
    
    
  
  
  • For narcolepsy:
    
    • Adults, teenagers, and children 12 years of age and older—At first, 10 mg daily. Your doctor may adjust your dose if needed.
    
    
    • Children 6 to 12 years of age—At first, 5 mg daily. Your doctor may increase your dose if needed.
    
    
    • Children younger than 6 years of age—Dose must be determined by your doctor .
    
    
  
  

• For oral dosage form (extended-release capsules):
  
  • For attention-deficit hyperactivity disorder:
    
    • Adults—20 milligrams (mg) once a day in the morning.
    
    
    • Children and teenagers 6 to 17 years of age—At first, 10 milligrams (mg) once a day in the morning. Your doctor may adjust your dose if needed.
    
    
    • Children younger than 6 years of age—Dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of amphetamine and dextroamphetamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using amphetamine and dextroamphetamine

It is very important that your doctor check your progress at regular visits to make sure amphetamine and dextroamphetamine is working properly and to check for unwanted effects .

If you will be taking amphetamine and dextroamphetamine in large doses for a long time, do not stop taking it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely .

Do not take amphetamine and dextroamphetamine within 14 days of taking an MAO inhibitor such as Eldepryl®, Marplan®, Nardil®, or Parnate®.

amphetamine and dextroamphetamine may cause some people to feel a false sense of well-being or to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to amphetamine and dextroamphetamine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) .

If you have been using amphetamine and dextroamphetamine for a long time and you think you may have become mentally or physically dependent on it, check with your doctor. Some signs of dependence on amphetamines are:

• A strong desire or need to continue taking the medicine.


• A need to increase the dose to receive the effects of the medicine.


• Withdrawal effects (for example, mental depression, nausea or vomiting, stomach cramps or pain, trembling, unusual tiredness or weakness) occurring after the medicine is stopped .

amphetamine and dextroamphetamine may cause slow growth. If your child is using amphetamine and dextroamphetamine, the doctor will need to keep track of your child's height and weight to make sure that your child is growing properly .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements .

Before you have any medical tests, tell the medical doctor in charge that you are taking amphetamine and dextroamphetamine. The results of some tests may be affected by amphetamine and dextroamphetamine .

amphetamine and dextroamphetamine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Bladder pain


• bloody or cloudy urine


• difficult, burning, or painful urination


• fast, pounding, or irregular heartbeat or pulse


• frequent urge to urinate


• lower back or side pain

Less common

• Cold flu-like symptoms


• cough or hoarseness


• fever or chills

Incidence not known

• Blistering, peeling, loosening of skin


• chest pain or discomfort


• confusion


• convulsions


• diarrhea


• difficulty breathing


• difficulty in speaking


• difficulty swallowing


• dizziness


• double vision


• faintness


• hallucinations (seeing, hearing, or feeling things that are not there)


• headache


• inability to move arms, legs, or facial muscles


• inability to speak


• itching


• joint or muscle pain


• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• loss of bladder control


• muscle spasm or jerking of all extremities


• nausea


• pain or discomfort in arms, jaw, back, or neck


• red irritated eyes


• red skin lesions, often with a purple center


• severe mental changes


• shortness of breath


• skin rash


• slow speech


• sore throat


• sores, ulcers, or white spots in mouth or on lips


• sudden loss of consciousness


• sweating


• swelling of feet or lower legs


• tightness in chest


• troubled breathing


• uncontrolled vocal outbursts and/or tics (uncontrolled repeated body movements)


• unusual tiredness or weakness


• vomiting


• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Blurred vision


• dark-colored urine


• discouragement


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• feeling sad or empty


• irritability


• lack of appetite


• loss of interest or pleasure


• muscle cramps or spasms


• muscle pain or stiffness


• nervousness


• overactive reflexes


• physical attempt to injure


• restlessness


• stomach cramps


• trembling or shaking of legs, arms, hands, or feet


• trouble concentrating


• trouble sleeping


• violent actions


• panic state


• pounding in the ears

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Anxiety


• dry mouth


• lack or loss of strength


• sleeplessness


• stomach pain


• unable to sleep


• weight loss

Incidence not known

• Constipation


• decreased interest in sexual intercourse


• false or unusual sense of well-being


• inability to have or keep an erection


• loss in sexual ability, desire, drive, or performance


• twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: amphetamine and dextroamphetamine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More amphetamine and dextroamphetamine resources

• Amphetamine and dextroamphetamine Side Effects (in more detail)
• Amphetamine and dextroamphetamine Use in Pregnancy & Breastfeeding
• Drug Images
• Amphetamine and dextroamphetamine Drug Interactions
• Amphetamine and dextroamphetamine Support Group
• 212 Reviews for Amphetamine and dextroamphetamine - Add your own review/rating

Compare amphetamine and dextroamphetamine with other medications

• ADHD
• Fatigue
• Narcolepsy

Enalapril / Hydrochloorthiazide Hexal

Enalapril / Hydrochloorthiazide Hexal may be available in the countries listed below.

Ingredient matches for Enalapril / Hydrochloorthiazide Hexal

Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Enalapril / Hydrochloorthiazide Hexal in the following countries:

• Netherlands

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Enalapril / Hydrochloorthiazide Hexal in the following countries:

• Netherlands

International Drug Name Search

Magnesio Solfato Salf

Magnesio Solfato Salf may be available in the countries listed below.

Ingredient matches for Magnesio Solfato Salf

Magnesium Sulfate

Magnesium Sulfate is reported as an ingredient of Magnesio Solfato Salf in the following countries:

• Italy

International Drug Name Search

Crafilm

Crafilm may be available in the countries listed below.

Ingredient matches for Crafilm

Sucralfate

Sucralfate is reported as an ingredient of Crafilm in the following countries:

• Italy

International Drug Name Search

Depnon

Depnon may be available in the countries listed below.

Ingredient matches for Depnon

Mianserin

Mianserin hydrochloride (a derivative of Mianserin) is reported as an ingredient of Depnon in the following countries:

• India

International Drug Name Search

Amoxicillina Sandoz

Amoxicillina Sandoz may be available in the countries listed below.

Ingredient matches for Amoxicillina Sandoz

Amoxicillin

Amoxicillin trihydrate (a derivative of Amoxicillin) is reported as an ingredient of Amoxicillina Sandoz in the following countries:

• Italy

International Drug Name Search

Medamol

Medamol may be available in the countries listed below.

Ingredient matches for Medamol

Codeine

Codeine phosphate hemihydrate (a derivative of Codeine) is reported as an ingredient of Medamol in the following countries:

• Greece

Paracetamol

Paracetamol is reported as an ingredient of Medamol in the following countries:

• Greece


• Oman

International Drug Name Search

Disalcid

Generic Name: salsalate (SAL sa late)

Brand Names: Disalcid, Salsitab

What is Disalcid (salsalate)?

Salsalate is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.

Salsalate is used to reduce pain, swelling, and joint stiffness caused by arthritis.

Salsalate may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Disalcid (salsalate)?

You should not use this medication if you are allergic to aspirin or to an NSAID (non-steroidal anti-inflammatory drug).

Before taking salsalate, tell your doctor if you have asthma, heart disease, high blood pressure, stomach or intestinal bleeding, diabetes, anemia, a bleeding disorder, liver or kidney disease, nasal polyps, a genetic enzyme deficiency, or if you are dehydrated.

This medicine may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use salsalate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking salsalate, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.

What should I discuss with my healthcare provider before taking Disalcid (salsalate)?

Salicylates may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use salsalate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Salicylates may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking salsalate, especially in older adults.

You should not use this medication if you are allergic to aspirin or to an NSAID (non-steroidal anti-inflammatory drug).

To make sure you can safely take salsalate, tell your doctor if you have any of these other conditions:

• 
  

  asthma;

  
  


• 
  

  heart disease, high blood pressure, congestive heart failure;

  
  


• 
  

  a history of stroke or heart attack;

  
  


• 
  

  a stomach ulcer or intestinal bleeding;

  
  


• 
  

  a bleeding or blood clotting disorder;

  
  


• 
  

  diabetes;

  
  


• 
  

  swelling or fluid retention;

  
  


• 
  

  anemia (a lack of red blood cells);

  
  


• liver disease;


• kidney disease;


• 
  

  an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);

  
  


• 
  

  nasal polyps; or

  
  


• 
  

  if you are dehydrated.

  
  

FDA pregnancy category C. Salsalate may be harmful to an unborn baby if the mother takes the medication during the last 3 months of pregnancy. Do not take this medication without telling your doctor if you are pregnant or plan to become pregnant during treatment. Salsalate can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children. Older adults may be more likely to have side effects from salsalate.

How should I take Disalcid (salsalate)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Salsalate may be taken up to 3 times per day. Follow your doctor's instructions.

Take the medicine with a full glass of water. Take salsalate with food, milk, or an antacid if it upsets your stomach. To prevent stomach upset, do not lie down for at least 30 minutes after taking salsalate. It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 2 weeks of treatment.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using salsalate.

If you need surgery, tell the surgeon ahead of time that you are using salsalate. You may need to stop using the medicine for a short time. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since salsalate is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include ringing in your ears, severe dizziness or drowsiness, sweating, fast breathing, severe vomiting or diarrhea, confusion, or seizure (convulsions).

What should I avoid while taking Disalcid (salsalate)?

Salsalate may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other over-the-counter medicine. Salicylates and NSAIDs are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains aspirin, ibuprofen, naproxen, ketoprofen, magnesium salicylate, or similar medicines.

If you are also taking low-dose aspirin because your doctor has prescribed it to prevent heart attack or stroke, do not stop taking it or change your dose without your doctor's advice. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.

Avoid drinking alcohol. It may increase your risk of stomach bleeding. Avoid smoking, since it can also increase your risk of stomach bleeding.

Disalcid (salsalate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;

  
  


• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  feeling like you might pass out;

  
  


• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  hearing problems, ringing in your ears;

  
  


• 
  

  swelling in your hands or feet, rapid weight gain;

  
  


• 
  

  fast or pounding heartbeats;

  
  


• 
  

  easy bruising or bleeding, fever, chills, sore throat, flu symptoms;

  
  


• 
  

  urinating more or less than usual;

  
  


• 
  

  severe stomach pain, ongoing nausea or vomiting; or

  
  


• 
  

  dark urine, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  upset stomach, heartburn; or

  
  


• 
  

  mild dizziness.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Disalcid (salsalate)?

Many drugs can interact with salsalate. Below is just a partial list. Tell your doctor if you are using:

• 
  

  acetazolamide (Diamox);

  
  


• 
  

  cyclosporine (Gengraf, Neoral, Sandimmune);

  
  


• 
  

  lithium (Eskalith, LithoBid);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  pemetrexed (Alimta);

  
  


• 
  

  tenofovir (Viread);

  
  


• 
  

  an antidepressant such as fluoxetine (Prozac) or sertraline (Zoloft);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  oral diabetes medication;

  
  


• 
  

  a diuretic (water pill);

  
  


• 
  

  gout medication such as probenecid (Benemid);

  
  


• 
  

  heart or blood pressure medication such as atenolol (Tenormin), captopril (Capoten), lisinopril (Prinivil, Zestril), losartan (Cozaar, Hyzaar), metoprolol (Lopressor, Toprol), and others;

  
  


• 
  

  medication used to prevent blood clots, such as cilostazol (Pletal) or clopidogrel (Plavix);

  
  


• 
  

  osteoporosis medication such as alendronate (Fosamax), ibandronate (Boniva), risedronate (Actonel), and others;

  
  


• 
  

  sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra);

  
  


• 
  

  seizure medication such as phenytoin (Dilantin), phenobarbital (Solfoton), valproic acid (Depakene); or

  
  


• 
  

  steroid medicine (prednisone and others).

  
  

This list is not complete and there are many other drugs that can interact with salsalate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More Disalcid resources

• Disalcid Side Effects (in more detail)
• Disalcid Use in Pregnancy & Breastfeeding
• Drug Images
• Disalcid Drug Interactions
• Disalcid Support Group
• 1 Review for Disalcid - Add your own review/rating

• Salsalate Prescribing Information (FDA)


• Salsalate Monograph (AHFS DI)


• Amigesic Advanced Consumer (Micromedex) - Includes Dosage Information


• Amigesic MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Disalcid with other medications

• Osteoarthritis
• Rheumatoid Arthritis

Where can I get more information?

• Your pharmacist can provide more information about salsalate.

See also: Disalcid side effects (in more detail)

Dapiprazole

Generic Name: Dapiprazole (da-PI-pray-zole)
Brand Name: Rev-Eyes

Dapiprazole is used for:

Decreasing the size of the pupil after certain eye examinations or surgery.

Dapiprazole is an antimydriatic. It works by blocking the smooth muscle contraction of the iris, which helps to decrease the size of the pupil.

Do NOT use Dapiprazole if:

• you are allergic to any ingredient in Dapiprazole


• you have acute iritis (inflammation of the front portion of the eye)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dapiprazole:

Some medical conditions may interact with Dapiprazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Dapiprazole. However, no specific interactions with Dapiprazole are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dapiprazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dapiprazole:

Use Dapiprazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Dapiprazole is usually administered at your doctor's office, hospital, or clinic.


• Dapiprazole is for use in the eye only. Avoid contact with other mucous membranes.


• Dapiprazole must be mixed before using. To use Dapiprazole, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them. To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including your eye. Keep the container tightly closed.


• If Dapiprazole is cloudy or discolored, do not use it.


• If you miss a dose of Dapiprazole, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Dapiprazole.

Important safety information:

• Dapiprazole may cause blurred vision or difficulty seeing in the dark. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dapiprazole. Using Dapiprazole alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Patients should not receive Dapiprazole more often than once per week.


• Use Dapiprazole with extreme caution in CHILDREN younger than 4 years of age. Safety and effectiveness in this age group have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Dapiprazole, discuss with your doctor the benefits and risks of using Dapiprazole during pregnancy. It is unknown if Dapiprazole is excreted in breast milk. If you are or will be breast-feeding while you are using Dapiprazole, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Dapiprazole:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; light sensitivity; redness and itching of the eyelids; redness or burning when you first put the medicine in your eye.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); swelling of the eyelid.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Dapiprazole side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Dapiprazole:

Store mixed medicine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), for 21 days. If Dapiprazole is cloudy or discolored, discard it. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dapiprazole out of the reach of children and away from pets.

General information:

• If you have any questions about Dapiprazole, please talk with your doctor, pharmacist, or other health care provider.


• Dapiprazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dapiprazole. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Dapiprazole resources

• Dapiprazole Side Effects (in more detail)
• Dapiprazole Use in Pregnancy & Breastfeeding
• Dapiprazole Support Group
• 0 Reviews · Be the first to review/rate this drug

Fenoximetilpenicilina Fabra

Fenoximetilpenicilina Fabra may be available in the countries listed below.

Ingredient matches for Fenoximetilpenicilina Fabra

Phenoxymethylpenicillin

Phenoxymethylpenicillin potassium (a derivative of Phenoxymethylpenicillin) is reported as an ingredient of Fenoximetilpenicilina Fabra in the following countries:

• Argentina

International Drug Name Search

Acenocoumarol Merck

Acenocoumarol Merck may be available in the countries listed below.

Ingredient matches for Acenocoumarol Merck

Acenocoumarol

Acenocoumarol is reported as an ingredient of Acenocoumarol Merck in the following countries:

• Netherlands

International Drug Name Search

Politosse

Politosse may be available in the countries listed below.

Ingredient matches for Politosse

Cloperastine

Cloperastine fendizoate (a derivative of Cloperastine) is reported as an ingredient of Politosse in the following countries:

• Italy

International Drug Name Search

Panfor

Panfor may be available in the countries listed below.

Ingredient matches for Panfor

Metformin

Metformin hydrochloride (a derivative of Metformin) is reported as an ingredient of Panfor in the following countries:

• Myanmar

International Drug Name Search

Dexamethasone Elixir

Dexamethasone Elixir, USP

(0.5 mg/5 mL)

Rx only

Dexamethasone Elixir Description

Each 5 mL (teaspoonful) contains:

Dexamethasone, USP                                                                     0.5 mg

Also contains:

Benzoic Acid, USP                                                                           0.1%

  (as preservative)

Alcohol                                                                                             5.1%

Inactive Ingredients: Artificial Raspberry Flavor; Citric Acid, USP; FD&C Red No. 40; Liquid Sugar; Propylene Glycol, USP and Purified Water, USP. It may also contain Sodium Citrate, USP.

Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract.

Dexamethasone, a synthetic adrenocortical steroid, is a white to practically white, odorless, crystalline powder. It is stable in air. It is practically insoluble in water. The molecular weight is 392.47. It is designated chemically as 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione. The molecular formula is C22H29FO5 and the structural formula is:

Dexamethasone Elixir - Clinical Pharmacology

Naturally occurring glucocorticoids, (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, including dexamethasone, are primarily used for their potent antiinflammatory effects in disorders of many organ systems.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

At equipotent anti-inflammatory doses, dexamethasone almost completely lacks the sodium-retaining property of hydrocortisone and closely related derivatives of hydrocortisone.

Indications and Usage for Dexamethasone Elixir

1. Endocrine Disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).
   
   Congenital adrenal hyperplasia
   
   Nonsuppurative thyroiditis
   
   Hypercalcemia associated with cancer


2. Rheumatic Disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:
   
   Psoriatic arthritis
   
   Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)
   
   Ankylosing spondylitis
   
   Acute and subacute bursitis
   
   Acute nonspecific tenosynovitis
   
   Acute gouty arthritis
   
   Post-traumatic osteoarthritis
   
   Synovitis of osteoarthritis
   
   Epicondylitis


3. Collagen Diseases: During an exacerbation or as maintenance therapy in selected cases of:
   
   Systemic lupus erythematosus
   
   Acute rheumatic carditis


4. Dermatologic Diseases:
   
   Pemphigus
   
   Bullous dermatitis herpetiformis
   
   Severe erythema multiforme (Stevens-Johnson syndrome)
   
   Exfoliative dermatitis
   
   Mycosis fungoides
   
   Severe psoriasis
   
   Severe seborrheic dermatitis


5. Allergic States: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:
   
   Seasonal or perennial allergic rhinitis
   
   Bronchial asthma
   
   Contact dermatitis
   
   Atopic dermatitis
   
   Serum sickness
   
   Drug hypersensitivity reactions


6. Ophthalmic Diseases: Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, such as:
   
   Allergic conjunctivitis
   
   Keratitis
   
   Allergic corneal marginal ulcers
   
   Herpes zoster ophthalmicus
   
   Iritis and iridocyclitis
   
   Chorioretinitis
   
   Anterior segment inflammation
   
   Diffuse posterior uveitis and choroiditis
   
   Optic neuritis
   
   Sympathetic ophthalmia


7. Respiratory Diseases:
   
   Symptomatic sarcoidosis
   
   Loeffler's syndrome not manageable by other means
   
   Berylliosis
   
   Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy
   
   Aspiration pneumonitis


8. Hematologic Disorders:
   
   Idiopathic thrombocytopenic purpura in adults
   
   Secondary thrombocytopenia in adults
   
   Acquired (autoimmune) hemolytic anemia
   
   Erythroblastopenia (RBC anemia)
   
   Congenital (erythroid) hypoplastic anemia


9. Neoplastic Diseases: For palliative management of:
   
   Leukemia and lymphomas in adults
   
   Acute leukemia of childhood


10. Edematous States: To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus


11. Gastrointestinal Diseases: To tide the patient over a critical period of the disease in:
    
    Ulcerative colitis
    
    Regional enteritis


12. Miscellaneous:
    
    Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
    
    Trichinosis with neurologic or myocardial involvement


13. Diagnostic testing of adrenocortical hyperfunction.

Contraindications

 

Systemic fungal infections

 

Hypersensitivity to this product

Warnings

In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.

Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. If the patient is receiving steroids already, dosage may have to be increased. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently.

Corticosteroids may mask some signs of infection, and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used. Moreover, corticosteroids may affect the nitroblue-tetrazolium test for bacterial infection and produce false-negative results.

In cerebral malaria, a double-blind trial has shown that the use of corticosteroids is associated with prolongation of coma and a higher incidence of pneumonia and gastrointestinal bleeding.

Corticosteroids may activate latent amebiasis. Therefore, it is recommended that latent or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea.

Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

Usage in Pregnancy

Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy or in women of childbearing potential requires that the anticipated benefits be weighed against the possible hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.

Corticosteroids appear in breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other unwanted effects. Mothers taking pharmacologic doses of corticosteroids should be advised not to nurse.

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion.

Administration of live virus vaccines, including smallpox, is contraindicated in individuals receiving immunosuppressive doses of corticosteroids. If inactivated viral or bacterial vaccines are administered to individuals receiving immunosuppressive doses of corticosteroids, the expected serum antibody response may not be obtained. However, immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy, e.g., for Addison's disease.

Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy individuals. Chickenpox and measles, for example, can have more serious or even fatal course in non-immune children or adults on corticosteroids. In such children or adults who have not had these diseases, particular care should be taken to avoid exposure. How the dose, route and duration of corticosteroid administration affects the risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZlG) may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chickenpox develops, treatment with antiviral agents may be considered.

The use of Dexamethasone Elixir in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen.

If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.

Literature reports suggest an apparent association between use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients.

Precautions

Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including fever, myalgia, arthralgia, and malaise. This may occur in patients even without evidence of adrenal insufficiency.

There is an enhanced effect of corticosteroids in patients with hypothyroidism and in those with cirrhosis.

Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.

The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual.

Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids.

Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.

Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess, or other pyogenic infection, diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer, renal insufficiency, hypertension, osteoporosis and myasthenia gravis. Fat embolism has been reported as a possible complication of hypercortisonism.

When large doses are given, some authorities advise that corticosteroids be taken with meals and antacids taken between meals to help to prevent peptic ulcer.

Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed.

Steroids may increase or decrease motility and number of spermatozoa in some patients.

Phenytoin, phenobarbital, ephedrine, and rifampin may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened physiologic activity, thus requiring adjustment in corticosteroid dosage. These interactions may interfere with dexamethasone suppression tests which should be interpreted with caution during administration of these drugs.

False-negative results in the dexamethasone suppression test (DST) in patients being treated with indomethacin have been reported. Thus, results of the DST should be interpreted with caution in these patients.

The prothrombin time should be checked frequently in patients who are receiving corticosteroids and coumarin anticoagulants at the same time because of reports that corticosteroids have altered the response to these anticoagulants. Studies have shown that the usual effect produced by adding corticosteroids is inhibition of response to coumarins, although there have been some conflicting reports of potentiation not substantiated by studies.

When corticosteroids are administered concomitantly with potassium-depleting diuretics, patients should be observed closely for development of hypokalemia.

Information for Patients

Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.

Adverse Reactions

Fluid and Electrolyte Disturbances:

 

Sodium retention

 

Fluid retention

 

Congestive heart failure in susceptible patients

 

Potassium loss

 

Hypokalemic alkalosis

 

Hypertension

Musculoskeletal:

 

Muscle weakness

 

Steroid myopathy

 

Loss of muscle mass

 

Osteoporosis

 

Vertebral compression fractures

 

Aseptic necrosis of femoral and humeral heads

 

Pathologic fracture of long bones

 

Tendon rupture

Gastrointestinal:

 

Peptic ulcer with possible perforation and hemorrhage

 

Perforation of the small and large bowel, particularly in patients with inflammatory bowel disease

 

Pancreatitis

 

Abdominal distention

 

Ulcerative esophagitis

Dermatologic:

 

Impaired wound healing

 

Thin fragile skin

 

Petechiae and ecchymoses

 

Erythema

 

Increased sweating

 

May suppress reactions to skin tests

 

Other cutaneous reactions, such as allergic dermatitis, urticaria, angioneurotic edema

Neurologic:

 

Convulsions

 

Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment

 

Vertigo

 

Headache

 

Psychic Disturbances

Endocrine:

 

Menstrual irregularities

 

Development of cushingoid state

 

Suppression of growth in children

 

Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness

 

Decreased carbohydrate tolerance

 

Manifestations of latent diabetes mellitus

 

Increased requirements for insulin or oral hypoglycemic agents in diabetes

 

Hirsutism

Ophthalmic:

 

Posterior subcapsular cataracts

 

Increased intraocular pressure

 

Glaucoma

 

Exophthalmos

Metabolic:

 

Negative nitrogen balance due to protein catabolism

Cardiovascular:

 

Myocardial rupture following recent myocardial infarction (See WARNINGS)

Other:

 

Hypersensitivity

 

Thromboembolism

 

Weight gain

 

Increased appetite

 

Nausea

 

Malaise

 

Hiccups

Overdosage

Reports of acute toxicity and/or death following overdosage of glucocorticoids are rare. In the event of overdosage, no specific antidote is available; treatment is supportive and symptomatic.

The oral LD50 of dexamethasone in female mice was 6.5 g/kg.

Dexamethasone Elixir Dosage and Administration

For oral administration: DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.

The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue Dexamethasone Elixir and transfer the patient to other therapy.

After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.

Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.

If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually.

The following milligram equivalents facilitate changing to Dexamethasone Elixir from other glucocorticoids:

Dexamethasone Elixir	METHYLPREDNI-SOLONE AND TRIAMCINOLONE	PREDNISOLONE AND PREDNISONE	HYDROCORTISONE	CORTISONE
0.75 mg =	4 mg =	5 mg =	20 mg =	25 mg

Dexamethasone suppression tests

1. Tests for Cushing's syndrome.
   
   Give 1 mg of Dexamethasone orally at 11:00 p.m. Blood is drawn for plasma cortisol determination at 8:00 a.m. the following morning.
   
   For greater accuracy, give 0.5 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.


2. Test to distinguish Cushing's syndrome due to pituitary ACTH excess from Cushing's syndrome due to other causes.
   
   Give 2 mg of Dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.

How is Dexamethasone Elixir Supplied

Dexamethasone Elixir 0.5 mg/5 mL is supplied as a clear, red, raspberry-flavored liquid in the following sizes:

100 mL fill in a 4 fl oz bottle with separately packaged dropper assembly. Dropper graduated for 0.125 mg and 0.25 mg.

8 fl oz (No Dropper) (237 mL)

RECOMMENDED STORAGE

Store at controlled room temperature, 15 °–30 °C (59 °–86 °F).

KEEP TIGHTLY CLOSED

AVOID FREEZING

Dispense in a tight container as defined in the USP.

Rx Only

Product No.: 8466

Manufactured By: Morton Grove Pharmaceuticals, Inc.

Morton Grove, IL 60053

A50-8466-08 REV. 04-08

PRINCIPAL DISPLAY PANEL - 237 mL Bottle Label

MGP

NDC 60432-466-08

DEXAMETHASONE

ELIXIR, USP

0.5 mg/5 mL

DO NOT USE IF TAMPER-EVIDENT

SEAL IS BROKEN OR MISSING.

Rx Only

NET: 8 fl oz (237 mL)

DEXAMETHASONE  dexamethasone  elixir

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 60432-466 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Dexamethasone (Dexamethasone) Dexamethasone 0.5 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength Sucrose   Propylene Glycol   Benzoic Acid   Alcohol   Water   Anhydrous Citric Acid   FD&C Red No. 40   Raspberry   Sodium Citrate

Product Characteristics Color RED Score      Shape Size Flavor RASPBERRY (Flavor Description) Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 60432-466-08 1 BOTTLE In 1 BOX contains a BOTTLE, GLASS 1 237 mL In 1 BOTTLE, GLASS This package is contained within the BOX (60432-466-08)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA088254	07/27/1983

Labeler - Morton Grove Pharmaceuticals, Inc. (801897505)

Establishment
Name	Address	ID/FEI	Operations
Pharmacia and Upjohn Company		829076566	API MANUFACTURE

Revised: 01/2012Morton Grove Pharmaceuticals, Inc.