Wednesday, December 28, 2011

DuraTan PE


Generic Name: chlorpheniramine, methscopolamine, and phenylephrine (KLOR fe NEER a meen, METH skoe POL a meen, FEN il EFF rin)

Brand Names: Aerohist Plus, Ah-Chew, Chlor-Mes, Dallergy (obsolete), Denaze, Duradryl, Durahist PE, DuraTan PE, Extendryl Chews, Histatab PH, Omnihist L.A., Ralix, Redur-PCM, Rescon MX


What is DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Methscopolamine is an anticholinergic (an-tye-kol-in-URJ-ik) that has a drying effect on the nasal passages.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of chlorpheniramine, methscopolamine, and phenylephrine is used to treat runny nose, sneezing, itchy throat, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.


Chlorpheniramine, methscopolamine, and phenylephrine may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?


Do not use this medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cold or allergy medicine before the MAO inhibitor has cleared from your body.

Before using this medicine, tell your doctor if you have heart disease, high blood pressure, or a heart rhythm disorder, circulation problems, glaucoma, diabetes, a thyroid disorder, kidney disease, or problems with urination.


Do not use any other over-the-counter cold, cough, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains chlorpheniramine or phenylephrine. Talk with your doctor if your symptoms do not improve after 5 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my health care provider before taking DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?


Do not take this medication if you are allergic to chlorpheniramine, methscopolamine, phenylephrine, or to other cold or allergy medicines, diet pills, stimulants, or ADHD medications. Do not use this medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cold or allergy medicine before the MAO inhibitor has cleared from your body.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:



  • heart disease, high blood pressure, or a heart rhythm disorder;




  • a blood vessel disorder or circulation problems;




  • glaucoma;




  • diabetes;




  • a thyroid disorder;




  • kidney disease;




  • asthma;




  • an enlarged prostate; or




  • problems with urination.




This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication can decrease breast milk production, and also may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.


How should I take DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cold medicine is usually taken for only a short time until your symptoms clear up.


Take this medicine with a full glass of water. It is best to take this medicine with food.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. The suspension liquid form should be shaken well just before you measure a dose.


Do not crush, chew, break, or open an extended-release tablet unless your doctor tells you to. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. However, some extended-release pills can be broken to split the dose. Ask your doctor or pharmacist if you have questions.

The chewable tablet must be chewed completely before you swallow it.


Tell your doctor if your symptoms do not improve after 5 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.


Store this medicine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include feeling restless or nervous, nausea, vomiting, extreme drowsiness, confusion, hallucinations, uneven heart rate, fainting, or seizure (convulsions).

What should I avoid while taking DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.


Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine or methscopolamine. Tell your doctor if you need to use any of these other medicines.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice.


Do not use any other over-the-counter cold, cough, or allergy medication without first asking your doctor or pharmacist. Chlorpheniramine and phenylephrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains chlorpheniramine or phenylephrine. Avoid drinking alcohol. It can add to drowsiness caused by an antihistamine.

DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;




  • confusion, hallucinations, unusual thoughts or behavior;




  • severe dizziness, anxiety, restless feeling, or nervousness;




  • urinating less than usual or not at all;




  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;




  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or




  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).



Less serious side effects may include:



  • blurred vision;




  • dry mouth;




  • nausea, stomach pain, constipation;




  • mild loss of appetite;




  • dizziness, drowsiness, headache;




  • problems with memory or concentration;




  • ringing in your ears;




  • restlessness or excitability (especially in children);




  • warmth, tingling, or redness under your skin;




  • cold feeling in your hands or feet;




  • sleep problems (insomnia); or




  • skin rash or itching.



This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?


Before taking this medication, tell your doctor if you are using any other antihistamine or decongestant pills, liquids, or nasal sprays. Also tell your doctor if you are using any of the following drugs:



  • pramlintide (Symlin);




  • aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);




  • an antidepressant such as amitriptyline (Elavil, Etrafon) or desipramine (Norpramin);




  • bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);




  • a diuretic (water pill), or medicines to treat high blood pressure, angina (chest pain), or other heart conditions;




  • medication to treat irritable bowel syndrome;




  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), risperidone (Risperdal), trazodone (Desyrel);




  • migraine headache medication such as sumatriptan (Imitrex), naratriptan (Amerge), zolmitriptan (Zomig), ergotamine (Ergostat, Ergomar); or




  • seizure medication such as carbamazepine (Carbatrol) or phenobarbital (Luminal, Solfoton).



This list is not complete and there may be other drugs that can interact with chlorpheniramine, methscopolamine, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More DuraTan PE resources


  • DuraTan PE Side Effects (in more detail)
  • DuraTan PE Use in Pregnancy & Breastfeeding
  • DuraTan PE Drug Interactions
  • DuraTan PE Support Group
  • 0 Reviews for DuraTan PE - Add your own review/rating


  • AH-Chew Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Aerohist Plus Sustained-Release and Long-Acting Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Allergy DN PE Prescribing Information (FDA)

  • Dallergy Syrup Prescribing Information (FDA)

  • Dehistine Prescribing Information (FDA)

  • Duravent-DA Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Rescon Prescribing Information (FDA)



Compare DuraTan PE with other medications


  • Nasal Congestion
  • Rhinitis


Where can I get more information?


  • Your pharmacist can provide more information about chlorpheniramine, methscopolamine, and phenylephrine.

See also: DuraTan PE side effects (in more detail)


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Monday, December 5, 2011

Doral


Generic Name: quazepam (Oral route)

KWAZ-e-pam

Commonly used brand name(s)

In the U.S.


  • Doral

Available Dosage Forms:


  • Tablet

Therapeutic Class: Hypnotic


Pharmacologic Class: Benzodiazepine, Long Acting


Uses For Doral


Quazepam is used to treat insomnia (trouble in sleeping). This medicine is for short-term (usually 7 to 10 days) use only. Quazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.


This medicine is available only with your doctor's prescription.


Before Using Doral


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of quazepam in children. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of quazepam in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may an adjustment in the dose in patients receiving quazepam.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersXStudies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Alfentanil

  • Amobarbital

  • Anileridine

  • Aprobarbital

  • Butabarbital

  • Butalbital

  • Carisoprodol

  • Chloral Hydrate

  • Chlorzoxazone

  • Codeine

  • Dantrolene

  • Ethchlorvynol

  • Fentanyl

  • Hydrocodone

  • Hydromorphone

  • Levorphanol

  • Meperidine

  • Mephenesin

  • Mephobarbital

  • Meprobamate

  • Metaxalone

  • Methocarbamol

  • Methohexital

  • Morphine

  • Morphine Sulfate Liposome

  • Oxycodone

  • Oxymorphone

  • Pentobarbital

  • Phenobarbital

  • Primidone

  • Propoxyphene

  • Remifentanil

  • Secobarbital

  • Sodium Oxybate

  • Sufentanil

  • Tapentadol

  • Thiopental

  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • St John's Wort

  • Theophylline

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Breathing problems or lung disease or

  • Depression—Use with caution. May make these conditions worse.

  • Kidney disease or

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

  • Sleep apnea (temporary stopping of breathing during sleep)—Should not be used in patients with this condition.

Proper Use of Doral


Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.


Take quazepam just before going to bed, when you are ready to go to sleep. This medicine works very quickly to put you to sleep.


This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets):
    • For insomnia (trouble in sleeping):
      • Adults—At first, 15 milligrams (mg) at bedtime. Your doctor may adjust your dose if needed.

      • Older adults—At first, 7.5 milligrams (mg) at bedtime. Your doctor may adjust your dose if needed.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Doral


It is very important that your doctor check your progress at regular visits to see if the medicine is working properly and to allow for changes in the dose.


Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Do not breastfeed while you are using this medicine.


If you develop any unusual and strange thoughts or behavior while you are taking quazepam, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.


This medicine may cause sleep-related behaviors such as driving a car (sleep-driving), walking (sleep-walking), having sex, making phone calls, or preparing and eating food while asleep or not fully awake. If these reactions occur, tell your doctor right away.


Quazepam may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking this medicine and call your doctor right away if you have itching, hives, hoarseness, nausea or vomiting, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth or throat while you are using this medicine.


This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.


This medicine may cause some people, especially older persons, to become drowsy or less alert than they are normally. Even though quazepam is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, or are not alert or able to see well.


Do not stop taking it without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.


If your condition does not improve within 7 to 10 days, or if it becomes worse, check with your doctor.


Doral Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Drowsiness

Less common
  • Dizziness

Rare
  • Anxiety

  • dry mouth

  • hyperventilation

  • increased muscle spasm

  • irregular heartbeats

  • irritability

  • nervousness

  • nightmares

  • restlessness

  • shaking

  • shortness of breath

  • trouble in sleeping

  • unusual excitement, nervousness, restlessness, or irritability

Incidence not known
  • Abdominal or stomach pain

  • changes in patterns and rhythms of speech

  • chills

  • clay-colored stools

  • dark urine

  • decrease in frequency of urination

  • decrease in urine volume

  • difficulty in passing urine (dribbling)

  • fever

  • headache

  • inability to move eyes

  • increased blinking or spasms of the eyelid

  • itching

  • loss of appetite

  • loss of bladder control

  • nausea

  • painful urination

  • rash

  • seizures

  • shakiness in the legs, arms, hands, or feet

  • sleeplessness

  • slurred speech

  • sticking out of the tongue

  • trembling or shaking of the hands or feet

  • trouble in breathing, speaking, or swallowing

  • unable to sleep

  • uncontrolled twisting movements of the neck, trunk, arms, or legs

  • unpleasant breath odor

  • unusual facial expressions

  • unusual tiredness or weakness

  • vomiting of blood

  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:


Symptoms of overdose
  • Change in consciousness

  • loss of consciousness

  • mood or mental changes

  • sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Acid or sour stomach

  • belching

  • heartburn

  • indigestion

  • stomach discomfort, upset, or pain

Incidence not known
  • Decreased interest in sexual intercourse

  • inability to have or keep an erection

  • increased in sexual ability, desire, drive, or performance

  • increased interest in sexual intercourse

  • loss in sexual ability, desire, drive, or performance

  • menstrual changes

  • sweating

  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Doral side effects (in more detail)



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More Doral resources


  • Doral Side Effects (in more detail)
  • Doral Use in Pregnancy & Breastfeeding
  • Drug Images
  • Doral Drug Interactions
  • Doral Support Group
  • 1 Review for Doral - Add your own review/rating


  • Doral MedFacts Consumer Leaflet (Wolters Kluwer)

  • Doral Concise Consumer Information (Cerner Multum)

  • Quazepam Professional Patient Advice (Wolters Kluwer)



Compare Doral with other medications


  • Insomnia