Top PLR Article Directory Saint Kitts and Nevis: July 2012

Tuesday, July 31, 2012

pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization

PEN-te-tate zink trye-SOE-dee-um

Available Dosage Forms:

Solution

Therapeutic Class: Heavy Metal Chelator

Uses For pentetate zinc trisodium

Pentetate Zinc Trisodium is used to remove harmful substances, such as plutonium, americium, or curium from your body.

pentetate zinc trisodium is available only with your doctor's prescription.

Before Using pentetate zinc trisodium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pentetate zinc trisodium, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pentetate zinc trisodium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of pentetate zinc trisodium in children with use in other age groups, pentetate zinc trisodium, when given by injection, is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of pentetate zinc trisodium in the elderly with use in other age groups.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of pentetate zinc trisodium

Harmful substances may accumulate in your bladder. Therefore, to increase the flow of urine and decrease the time your bladder contains these harmful substances, your doctor may instruct you to drink plenty of liquids and urinate often while being treated with pentetate zinc trisodium to help eliminate the harmful substances.

Dosing

The dose of pentetate zinc trisodium will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pentetate zinc trisodium. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For inhalation dosage form:
- To help with the removal of harmful substances in individuals breathing in the harmful substances
  - Adults—1 gram once a day.
  - Children—Use and dose must be determined by your doctor.

For parenteral dosage form:
- To help with the removal of harmful substances in individuals exposed by some other way than breathing in the substances
  - Adults—1 gram once a day.
  - Children—14 milligrams per kilogram (mg/kg) once a day, not to exceed 1 gram.

Precautions While Using pentetate zinc trisodium

To prevent radiation contamination of other persons or environment:

Using a normal toilet instead of a urinal

Flushing toilet several times after each use

Completely cleaning up any spilled urine with a tissue and flushing it away

Washing hands thoroughly with soap after urinating or a bowel movement

Immediately laundering clothes and linens soiled with urine, feces or blood; washing them separately from other clothes

Avoid swallowing any solid substances that may be coughed up. Dispose of solid substances in sink or toilet. Flush several times if put in toilet or flush sink by washing hands thoroughly with soap after disposal.

Extra precaution in handling urine, feces, and substances coughed up by children to avoid additional exposure to the caregiver or to the child.

If you are breast-feeding your baby, talk to your doctor about how long you must formula feed your baby and how to dispose of the breast milk containing harmful substances.

pentetate zinc trisodium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence unknown

Cough

headache

lightheadedness

pelvic pain

wheezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: pentetate zinc trisodium Intravenous, Inhalation,/nebulization side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization resources

Pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization Side Effects (in more detail)
Pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization Use in Pregnancy & Breastfeeding
Pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization Support Group
0 Reviews for Pentetate zinc trisodium Intravenous, Inhalation,/nebulization - Add your own review/rating

Compare pentetate zinc trisodium Intravenous, Inhalation, oral/nebulization with other medications

Radiation Emergency

Monday, July 30, 2012

argatroban

Generic Name: argatroban (ar GAT roe ban)

Brand Names: Acova

What is argatroban?

Argatroban keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur while receiving heparin

Argatroban is used to treat or prevent blood clots in people who have thrombocytopenia (low levels of platelets in the blood) caused by using heparin. Argatroban is sometimes used in people who are undergoing a procedure called angioplasty (to open blocked arteries).

Argatroban may also be used for purposes not listed in this medication guide.

What is the most important information I should know about argatroban?

You should not use this medication if you are allergic to argatroban, or if you have any major bleeding from a surgery, injury, or other medical trauma. Argatroban is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with argatroban, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Before receiving argatroban, tell your doctor if you have liver disease, a stomach ulcer or bleeding, a bleeding or blood clotting disorder, untreated or uncontrolled high blood pressure, if you have recently had a spinal tap or epidural anesthesia, or if you have recently had major surgery (especially on your eyes, brain, or spinal cord).

Tell your doctor if you are using or receiving blood thinners or any other medications used to treat or prevent blood clots.

Because argatroban keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

What should I discuss with my health care provider before receiving argatroban?

You should not receive this medication if you are allergic to argatroban, or if you have any major bleeding from a surgery, injury, or other medical trauma.

To make sure you can safely use argatroban, tell your doctor if you have any of these other conditions:

a stomach ulcer or bleeding;

liver disease;

a bleeding or blood clotting disorder (such as hemophilia);

untreated or uncontrolled high blood pressure (hypertension);

if you have recently had a spinal tap or epidural anesthesia; or

if you have recently had major surgery (especially eye surgery, brain surgery, or spinal cord surgery).

Argatroban is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with argatroban, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether argatroban passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is argatroban given?

Argatroban is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Argatroban is sometimes given together with aspirin.

If you are receiving this injection during an angioplasty procedure, the medicine will be given throughout the entire procedure and for up to 24 hours after the procedure.

Argatroban is given around the clock until your blood coagulates properly. Your doctor will test your blood often to determine how long to treat you with argatroban.

To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly.

What happens if I miss a dose?

Since argatroban is given by a healthcare professional, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while receiving argatroban?

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Avoid drinking alcohol. It may increase your risk of bleeding in your stomach or intestines.

Argatroban side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

feeling like you might pass out;

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

blood in your urine;

black, bloody, or tarry stools;

coughing up blood or vomit that looks like coffee grounds;

any bleeding that will not stop;

pain or burning when you urinate;

sudden numbness or weakness, problems with vision, speech, or balance;

sudden severe headache, confusion, sudden changes in your senses of taste or touch;

fever, chills, body aches, flu symptoms;

cough with yellow or green mucus, stabbing chest pain, feeling short of breath;

slow heart rate, weak pulse, slow breathing (breathing may stop); or

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may include:

nausea, vomiting, diarrhea, stomach pain;

headache;

back pain; or

bleeding around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Argatroban Dosing Information

Usual Adult Dose for Thrombotic/Thromboembolic Disorder:

Heparin-induced thrombocytopenic (HIT) thrombosis treatment or prophylaxis:
Initial: 2 mcg/kg/min administered as a constant infusion. Begin infusion only after obtaining a baseline activated partial thromboplastin time (aPTT).
Maintenance: The infusion rate may be adjusted as needed (not to exceed 10 mcg/kg/min) until the steady state aPTT value is 1.5 to 3 times the initial baseline value (not to exceed 100 seconds). Dosage adjustments should be based on aPTT results from blood samples obtained at least 2 hours after the most recent infusion rate change.

Percutaneous Coronary Interventions (PCI) in HIT/HITTS patients:
Initial: 25 mcg/kg/min infusion and a bolus of 350 mcg/kg administered via a large bore intravenous line over 3 to 5 minutes. Activated clotting time (ACT) should be checked 5 to 10 minutes after the bolus dose is completed. The procedure may proceed if the ACT is greater than 300 seconds.
If the ACT is less than 300 seconds, an additional IV bolus dose of 150 mcg/kg should be administered, the infusion dose increased to 30 mcg/kg/min, and the ACT checked 5 to 10 minutes later. If the ACT is greater than 450 seconds, the infusion rate should be decreased to 15 mcg/kg/min, and the ACT checked 5 to 10 minutes later. Once a therapeutic ACT (between 300 and 450 seconds) has been achieved, this infusion dose should be continued for the duration of the procedure.

Usual Pediatric Dose for Thrombotic/Thromboembolic Disorder:

Infants and Children 16 years or younger: The safety and effectiveness of argatroban, including the appropriate anticoagulation goals and duration of therapy, have not been established among pediatric patients.

Note: Limited data available; dosing regimens not established. Titration of maintenance dose must consider multiple factors including current argatroban dose, current aPTT, target aPTT, and clinical status of the patient. For specific uses, required maintenance dose is highly variable between patients. Additionally, during the course of treatment, patient's dosing requirements may change as clinical status changes (e.g., sicker patients require lower dose); frequent dosage adjustments may be required to maintain desired anticoagulant activity. If argatroban therapy is used concurrently with or following FFP or a thrombolytic, some centers decrease dose by half.

Heparin-induced thrombocytopenia:
Initial dose: 0.75 mcg/kg/minute by continuous IV infusion
Maintenance dose: Measure aPTT after 2 hours; adjust dose until the steady-state aPTT is 1.5 to 3 times the initial baseline value, not exceeding 100 seconds; adjust in increments of 0.1 to 0.25 mcg/kg/minute for normal hepatic function; reduce dose in hepatic impairment (see liver dose adjustment).
Note: A lower initial infusion rate may be needed in other pediatric patients with reduced clearance of argatroban (e.g., patients with heart failure, multiple organ system failure, severe anasarca, or postcardiac surgery). This precaution is based on adult studies of patients with these disease states who had reduced argatroban clearance.

What other drugs will affect argatroban?

Tell your doctor about all other medications you use or have recently received to prevent blood clots, such as:

a blood thinner such as heparin or warfarin (Coumadin, Jantoven);

abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat);

dabigatran (Pradaxa), bivalirudin (Angiomax), lepirudin (Refludan);

dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep); or

alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase).

This list is not complete and other drugs may interact with argatroban. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More argatroban resources

Argatroban Side Effects (in more detail)
Argatroban Dosage
Argatroban Use in Pregnancy & Breastfeeding
Argatroban Drug Interactions
Argatroban Support Group
0 Reviews for Argatroban - Add your own review/rating

argatroban Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information

Argatroban Prescribing Information (FDA)

Argatroban Professional Patient Advice (Wolters Kluwer)

Argatroban Monograph (AHFS DI)

Argatroban MedFacts Consumer Leaflet (Wolters Kluwer)

Compare argatroban with other medications

Thrombotic/Thromboembolic Disorder

Where can I get more information?

Your doctor or pharmacist can provide more information about argatroban.

See also: argatroban side effects (in more detail)

ziconotide Intrathecal

zye-KON-oh-tide

Intrathecal route(Solution)

Ziconotide is contraindicated in patients with a preexisting history of psychosis. Severe psychiatric symptoms and neurological impairment may occur during treatment with ziconotide. Monitor all patients frequently for evidence of cognitive impairment, hallucinations, or changes in mood or consciousness. Discontinue ziconotide therapy in the event of serious neurological or psychiatric signs or symptoms .

Commonly used brand name(s)

In the U.S.

Prialt

Available Dosage Forms:

Solution

Therapeutic Class: Analgesic

Pharmacologic Class: Calcium Channel Blocker

Uses For ziconotide

Ziconotide injection is used to relieve severe chronic pain in patients who have already been treated with other medicines (e.g., morphine) and did not work well.

ziconotide is to be given only by or under the direct supervision of a doctor.

Before Using ziconotide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ziconotide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ziconotide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ziconotide injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ziconotide injection in the elderly. However, elderly patients are more likely to have confusion and age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving ziconotide injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Proper Use of ziconotide

A doctor or other trained health professional will give you ziconotide in a hospital. ziconotide is given through a needle or catheter into your back using a special infusion pump.

Precautions While Using ziconotide

It is very important that your doctor check your progress closely while you are receiving ziconotide. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

ziconotide may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Serious infection or meningitis can occur if the catheter of ziconotide becomes disconnected. It is very important that you follow your doctor's instructions about the care of the catheter and the use of the infusion pump.

If you or your caregiver notice any signs of meningitis such as confusion, drowsiness, fever, headache, nausea or vomiting, seizures, or stiff neck, call your doctor right away.

ziconotide may cause some people to become dizzy, drowsy, confused, disoriented, clumsy, or less alert than they are normally. Make sure you know how you react to ziconotide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

ziconotide will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before you take any of the medicines listed above while you are using ziconotide.

Tell your doctor right away if you have unexplained muscle pain or weakness, loss of strength or energy, and with or without a darkened urine. Your doctor may need to reduce the dose of your medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

ziconotide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Anxiety

being forgetful

change in walking and balance

changes in patterns and rhythms of speech

clumsiness or unsteadiness

confusion

decrease in the frequency of urination

decrease in urine volume

delusions

dementia

difficulty in passing urine (dribbling)

difficulty with speaking

feeling unusually cold

painful urination

problems with speech or speaking

seeing, hearing, or feeling things that are not there

shakiness and unsteady walk

shakiness in the legs, arms, hands, or feet

shivering

slurred speech

thoughts of killing oneself

trembling or shaking of the hands or feet

uncontrolled eye movements

unsteadiness, trembling, or other problems with muscle control or coordination

Less common

Aggressive or angry

chest pain

chills

confusion as to time, place, or person

convulsions

cough

dark-colored urine

dizziness

drowsiness

fainting

fast heartbeat

fearfulness, suspiciousness, or other mental changes

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

fever

general feeling of illness

holding false beliefs that cannot be changed by fact

lightheadedness

muscle spasm or jerking of all extremities

muscle stiffness

rapid, shallow breathing

severe mood or mental changes

shortness of breath

sneezing

sore throat

stiff neck or back

tightness in the chest

troubled breathing

trouble in concentration

trouble in sleeping

unusual behavior unusual excitement, nervousness, or restlessness

unusual tiredness or weakness

wheezing

Rare

Actions that are out of control

changes in behavior

irritability

talking, feeling, and acting with excitement

Incidence not known

Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Decreased awareness or responsiveness

severe sleepiness

More common

Blurred vision

crawling feelings

diarrhea

dizziness

dizziness or lightheadedness

excessive muscle tone, tension, or tightness

feeling of constant movement of self or surroundings

headache

itching

lack or loss of strength

loss of appetite

loss of memory

nausea

pain in the arms or legs

problems with memory

sensation of spinning

sleepiness or unusual drowsiness

vomiting

weight loss

Less common

Acid or sour stomach

back pain

bad, unusual, or unpleasant (after) taste

belching

bladder pain

bloody or cloudy urine

bruising

change in taste

congestion

constipation

continuing ringing or buzzing or other unexplained noise in the ears

crying

dehydration

depersonalization

depression

difficulty seeing at night

difficulty with moving

double vision

dry mouth

dry skin

dysphoria

euphoria

fainting

frequent urge to urinate

hearing loss

heartburn

hoarseness

increased sensitivity of the eyes to sunlight

increased sensitivity to pain or touch

indigestion

loss of bladder control

loss of taste

lung disorder

nerve pain

pain in the joints

pain or tenderness around the eyes and cheekbones

pale skin

pounding in the ears

quick to react or overreact emotionally

rapidly changing moods

red, scaly, swollen, or peeling areas of the skin

redness or pain at the catheter site

runny nose

severe muscle stiffness

shortness of breath or troubled breathing

sleeplessness

slow or fast heartbeat

stomach discomfort, upset, or pain

stuffy nose

sweating

swelling or redness in the joints

tender, swollen glands in the neck

tightness of the chest or wheezing

trouble with swallowing

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

warmth on the skin

weakness or heaviness in the legs

Incidence not known

Burning sensation on the skin

flaking and falling off of skin

skin blisters

sores on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: ziconotide Intrathecal side effects (in more detail)

More ziconotide Intrathecal resources

Ziconotide Intrathecal Side Effects (in more detail)
Ziconotide Intrathecal Use in Pregnancy & Breastfeeding
Ziconotide Intrathecal Drug Interactions
Ziconotide Intrathecal Support Group
0 Reviews for Ziconotide Intrathecal - Add your own review/rating

Compare ziconotide Intrathecal with other medications

Pain

Sunday, July 29, 2012

Duphalac 200ml

Duphalac

3.35g/5ml lactulose solution

Relieves Constipation

200ml

Duphalac

3.35g/5ml, Lactulose solution

Read all of this leaflet carefully because it contains important information for you.

This medicine is available without prescription. However, you still need to take Duphalac carefully to get the best results from it.

Keep this leaflet. You may need to read it again.

Ask your pharmacist if you need more information or advice.

You should contact a doctor if your symptoms worsen or do not improve.

If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

In this leaflet:

1. What Duphalac is and what it is used for

2. Before you take Duphalac

3. How to take Duphalac

4. Possible side effects

5. How to store Duphalac

6. Further information

What Duphalac is and what it is used for

Duphalac contains a medicine called lactulose. This belongs to a group of medicines called laxatives.

Duphalac is used to treat constipation. It is also sometimes used to treat a liver problem called ‘hepatic encephalopathy’.

This is also known as a ‘hepatic coma’.

Before you take Duphalac

Do not take Duphalac if:

You are allergic (hypersensitive) to lactulose or any of the other ingredients of Duphalac (listed in Section 6).

You have a rare problem called ‘galactosaemia’.

You have a blockage caused by anything else but normal constipation

Do not take Duphalac if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Duphalac.

Pregnancy and breast-feeding

Talk to your doctor before taking this medicine if you are pregnant, might become pregnant or are breast-feeding.

Ask your doctor or pharmacist for advice before taking any medicine, if you are pregnant or breast-feeding. Duphalac is safe to take in normal doses during pregnancy and when breast-feeding.

Important information about some of the ingredients of Duphalac

Duphalac contains fructose, galactose and lactose (all are types of sugar). If you have been told by your doctor that you cannot tolerate or digest some sugars (have an intolerance to some sugars), talk to your doctor before taking this medicine.

How to take Duphalac

If this medicine is from your doctor or pharmacist, do exactly as they have told you. Otherwise follow the instructions below. If you do not understand the instructions, or you are not sure, ask your doctor or pharmacist.

Taking this medicine

Take Duphalac from a spoon or measuring cup.

You can mix it with fruit juice or water.

Duphalac takes 2 to 3 days to start working.

After this time you may be able to reduce the dose you take according to your needs.

Constipation

Adults: The usual starting dose is 15 ml twice a day.

Children 5 to 10 years: The usual starting dose is 10 ml twice a day.

Children under 5 years: The usual starting dose is 5 ml twice a day

Babies under 1 year: The usual starting dose is 2.5 ml twice a day.

Hepatic encephalophathy

Adults: The usual starting dose is 30 to 50ml three times a day.

If you take more Duphalac than you should

If you take more Duphalac than you should, talk to a doctor. You may have diarrhoea.

If you forget to take Duphalac

If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose.

Do not take a double dose to make up for a forgotten dose.

Duphalac 200ml Side Effects

Like all medicines, Duphalac can cause side effects, although not everybody gets them. The following side effects may happen with this medicine:

Increased wind and feeling bloated. This may happen during the first few days of treatment. These effects usually disappear after a few days.

Diarrhoea. This may happen if you take high doses of Duphalac. If this happens, lower your dose.

If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How to store Duphalac

Keep out of the reach and sight of children.

Do not use Duphalac after the expiry date on the bottle.

Do not store above 25°C. Do not refrigerate or freeze.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further information

What Duphalac contains

The active substance is lactulose. Each 5ml of Duphalac contains 3.35g of lactulose.

The other ingredients are water, lactose, galactose, epilactose, fructose, tagatose, hydrogen peroxide and sodium hydroxide.

What Duphalac looks like and contents of the pack

Duphalac is a colourless or yellow liquid.

Duphalac is available in plastic bottles containing 200ml, 300ml, 500ml and 1000ml.

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

The Marketing Authorisation Holder is

Solvay Healthcare Limited

Southampton

SO18 3JD

The manufacturer is

Solvay Biologicals B.V.

8121 AA

OIst

The Netherlands

This leaflet was last approved in April 2009.

If you wish to receive this PIL in Braille, large font or audio format please contact 023 8046 7000.

Remember

This medicine is for you.

Please do not offer it to your family and friends, even if they have the same symptoms as you.

Duphalac

3.35g/5ml lactulose solution

Relieves Constipation

Duphalac contains a medicine called lactulose.

Each 5ml of Duphalac contains 3.35g of lactulose.

200ml

Duphalac contains a medicine called lactulose.

Each 5ml of Duphalac contains 3.35g of lactulose.

Duphalac contains fructose, galactose and lactose (all are types of sugar).

If you have been told by your doctor that you cannot tolerate or digest some sugars (have an intolerance to some sugars), talk to your doctor before taking this medicine.

Duphalac is a colourless or yellow liquid. Duphalac is available in plastic bottles containing:

200ml, 300ml, 500ml, 1000ml.

Read the package leaflet before use.

Keep out of the reach and sight of children.

Do not use Duphalac after the expiry date on the bottle.

Do not store above 25°C. Do not refrigerate or freeze.

This medicine is available without prescription. Duphalac is used to treat constipation. It is also sometimes used to treat a liver problem called ‘hepatic encephalopathy’.

This is also known as a ‘hepatic coma’.

RF1594

Solvay Healthcare

PL 00512/5001R

The Marketing Authorisation Holder is

Solvay Healthcare Limited

Southampton

SO18 3JD

trade mark

PIP 212-2620

RF1594

Centocor Ortho Biotech, Inc

Address

Centocor Ortho Biotech, Inc,
800 Ridgeview Rd.

Horsham, PA 19044

Contact Details

Phone: 1 (800) 457-6399
Website: http://www.centocororthobiotech.com/cobi/index.html
Careers: http://www.centocororthobiotech.com...

Thursday, July 26, 2012

Ciloxan Ointment

Pronunciation: sip-row-FLOX-ah-sin
Generic Name: Ciprofloxacin
Brand Name: Ciloxan

Ciloxan Ointment is used for:

Treating eye infections caused by certain bacteria.

Ciloxan Ointment is a quinolone antibiotic. It works by killing sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Do NOT use Ciloxan Ointment if:

you are allergic to any ingredient in Ciloxan Ointment or any other fluoroquinolone antibiotic (eg, levofloxacin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ciloxan Ointment:

Some medical conditions may interact with Ciloxan Ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you wear contact lenses

Some MEDICINES MAY INTERACT with Ciloxan Ointment. Because little, if any, of Ciloxan Ointment is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Ciloxan Ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ciloxan Ointment:

Use Ciloxan Ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ciloxan Ointment may be used around the eye or in the eye. To use Ciloxan Ointment in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using Ciloxan Ointment, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue.

To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.

Do not wear contact lenses while you are using Ciloxan Ointment. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.

To clear up your infection completely, take/use Ciloxan Ointment for the full course of treatment. Keep taking/using it even if you feel better in a few days.

If you miss a dose of Ciloxan Ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ciloxan Ointment.

Important safety information:

Ciloxan Ointment may cause blurred vision or sensitivity to light. Use Ciloxan Ointment with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not use leftover medicine for treating other infections or conditions without checking with your doctor.

Be sure to use Ciloxan Ointment for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Ciloxan Ointment may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Ciloxan Ointment should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ciloxan Ointment while you are pregnant. It is not known if Ciloxan Ointment is found in breast milk after topical use. If you are or will be breast-feeding while you use Ciloxan Ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ciloxan Ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloodshot eyes; blurred vision; burning or discomfort; crusting of eyelids; dry eyes; feeling of something in the eye; sensitivity to light.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; irritation; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ciloxan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Ciloxan Ointment:

Store Ciloxan Ointment between 36 and 77 degrees F (2 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ciloxan Ointment out of the reach of children and away from pets.

General information:

If you have any questions about Ciloxan Ointment, please talk with your doctor, pharmacist, or other health care provider.

Ciloxan Ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ciloxan Ointment. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Ciloxan resources

Ciloxan Side Effects (in more detail)
Ciloxan Dosage
Ciloxan Use in Pregnancy & Breastfeeding
Ciloxan Support Group
0 Reviews for Ciloxan - Add your own review/rating

Compare Ciloxan with other medications

Conjunctivitis, Bacterial
Corneal Ulcer
Ophthalmic Surgery

Wednesday, July 25, 2012

Norpace CR Sustained-Release Capsules

Pronunciation: dye-soe-PEER-a-mide
Generic Name: Disopyramide
Brand Name: Norpace CR

Norpace CR Sustained-Release Capsules sometimes produces new irregular heartbeats (arrhythmias). Therefore, it should be used in carefully selected patients. Consult your doctor or pharmacist for more information.

Norpace CR Sustained-Release Capsules are used for:

Correcting or preventing various types of life-threatening irregular heartbeats and heart rhythm disturbances.

Norpace CR Sustained-Release Capsules are an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (antiarrhythmic effect).

Do NOT use Norpace CR Sustained-Release Capsules if:

you are allergic to any ingredient in Norpace CR Sustained-Release Capsules

you have second- or third-degree heart block and do not have a pacemaker, you were born with an irregular heartbeat due to QT prolongation, or your heart is in shock

you are taking astemizole, cisapride, a class III antiarrhythmic (eg, amiodarone, sotalol), a phenothiazine (eg, thioridazine), pimozide, or a quinolone (eg, grepafloxacin, sparfloxacin), or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Norpace CR Sustained-Release Capsules:

Some medical conditions may interact with Norpace CR Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of certain heart conditions or irregular heart rhythms (eg, enlargement or inflammation of the heart, heart block, heart failure, heart attack, Wolff-Parkinson-White syndrome), diabetes, glaucoma, severe muscle weakness, high or low levels of potassium in the blood, or kidney or liver disease

if you have difficulty urinating due to an obstruction of the bladder neck or prostate problems

Some MEDICINES MAY INTERACT with Norpace CR Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Astemizole, beta-blockers (eg, propranolol), cisapride, class III antiarrhythmics (eg, amiodarone, sotalol), dofetilide, droperidol, ketolides (eg, telithromycin), macrolides (eg, erythromycin), phenothiazine (eg, thioridazine), pimozide, quinolones (eg, sparfloxacin, grepafloxacin), terfenadine, verapamil, or ziprasidone because side effects, such as life threatening irregular heartbeats, may be increased

Hydantoins (eg, phenytoin) because the effectiveness of Norpace CR Sustained-Release Capsules may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Norpace CR Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Norpace CR Sustained-Release Capsules:

Use Norpace CR Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Norpace CR Sustained-Release Capsules may be taken with or without food.

Swallow Norpace CR Sustained-Release Capsules whole. Do not break, crush, or chew before swallowing.

Norpace CR Sustained-Release Capsules works best if it is taken at the same time each day.

If you miss a dose of Norpace CR Sustained-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Norpace CR Sustained-Release Capsules.

Important safety information:

Norpace CR Sustained-Release Capsules may cause dizziness or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Norpace CR Sustained-Release Capsules.

Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Norpace CR Sustained-Release Capsules.

Use Norpace CR Sustained-Release Capsules with caution in the ELDERLY because they may be more sensitive to its effects.

Use Norpace CR Sustained-Release Capsules with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Norpace CR Sustained-Release Capsules during pregnancy. Norpace CR Sustained-Release Capsules are excreted in breast milk. Do not breast-feed while taking Norpace CR Sustained-Release Capsules.

Possible side effects of Norpace CR Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Aches or pain; bloating; blurred vision; constipation; difficulty urinating; dizziness; dryness of the eyes, mouth, nose, or throat; fatigue; frequent and urgent urination; gas; general body discomfort; headache; muscle weakness; nausea; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or slow heartbeat; fever; lightheadedness; heart rhythm problems; severe difficulty urinating; shortness of breath; sore throat; swelling.

See also: Norpace CR side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing; change in heart rhythm; loss of consciousness.

Proper storage of Norpace CR Sustained-Release Capsules:

Store Norpace CR Sustained-Release Capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Norpace CR Sustained-Release Capsules out of the reach of children and away from pets.

General information:

If you have any questions about Norpace CR Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.

Norpace CR Sustained-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Norpace CR Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Norpace CR resources

Norpace CR Side Effects (in more detail)
Norpace CR Use in Pregnancy & Breastfeeding
Drug Images
Norpace CR Drug Interactions
Norpace CR Support Group
2 Reviews for Norpace CR - Add your own review/rating

Compare Norpace CR with other medications

Arrhythmia

Monday, July 23, 2012

Fluzone

Generic Name: influenza virus vaccine (Intradermal route, Intramuscular route)

in-floo-EN-za VYE-rus VAX-een (sub-VEER-ee-on)

Commonly used brand name(s)

In the U.S.

Afluria

Fluarix

Flulaval

Fluvirin

Fluzone

Fluzone High-Dose

Fluzone Pediatric

Available Dosage Forms:

Suspension

Solution

Therapeutic Class: Vaccine

Uses For Fluzone

Influenza virus vaccine is used to prevent infection by the influenza viruses. The vaccine works by causing your body to produce its own protection (antibodies) against the disease. It is also known as a “flu shot”.

There are many kinds of influenza viruses, but not all will cause problems in any given year. Therefore, before the influenza vaccine is produced each year, the World Health Organization (WHO) and the U.S. and Canadian Public Health Services decide which viruses will most likely cause influenza infections for that year. The antigens, which are substances that cause protective antibodies to be formed, for these viruses are included in the influenza vaccine. Usually, the U.S. and Canada use the same influenza vaccine; however, they are not required to do so.

It is necessary to receive an influenza vaccine injection each year, since influenza infections are usually caused by different kinds of viruses and the protection gained by the vaccine lasts less than a year.

Influenza is a virus infection of the throat, bronchial tubes, and lungs. Influenza infection causes fever, chills, cough, headache, muscle aches, and pains in your back, arms, and legs. In addition, adults and children weakened by other diseases or medical conditions, and persons 50 years of age and over, even if they are healthy, may get a much more serious illness that may have to be treated in a hospital. Each year thousands of people die as a result of an influenza infection.

The best way to help prevent influenza infections is to get an influenza vaccination each year, usually in early November. Immunization (getting a vaccine) against influenza is approved for infants 6 months of age and older, all children, and all adults (including 65 years of age and older).

This vaccine is to be administered only by or under the supervision of your doctor or other health care professional.

Before Using Fluzone

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of Agriflu®, Flulaval™, Fluzone® High-Dose, or Fluzone® Intradermal in the pediatric population. Safety and efficacy have not been established.

Afluria® is not indicated in children younger than 5 years of age. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Fluvirin® in children younger than 4 years of age. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Fluarix® in children younger than 3 years of age. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Fluzone® in children younger than 6 months of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of influenza virus vaccine in the elderly.

Appropriate studies have not been performed on the relationship of age to the effects of Fluzone® Intradermal in the geriatric population. Safety and efficacy have not been established.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Proper Use of influenza virus vaccine

This section provides information on the proper use of a number of products that contain influenza virus vaccine. It may not be specific to Fluzone. Please read with care.

A nurse or other trained health professional will give you or your child this vaccine. This vaccine is given as a shot into one of your muscles or into your skin, usually in the shoulder area.

Sometimes there is not enough flu vaccine for everyone. If this happens and you are a healthy adult, you might need to wait until later in the flu season before getting your vaccination.

You need to get the flu vaccine every year to protect you from the flu.

Some children may need a second dose of the vaccine. If your child needs a second dose of this medicine, it is very important for your child to receive the second dose on schedule. If you must cancel the appointment, make another appointment as soon as possible.

Precautions While Using Fluzone

It is very important that your child return to your doctor’s office at the right time if your child needs a second dose of the vaccine. Be sure to notify your doctor of any side effects that occur after you or your child receive this vaccine.

This vaccine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, itching, swelling of the tongue and throat, or troubled breathing after you get the injection.

Children who have received a certain brand of the influenza vaccine (Afluria®) have developed a fever and in some cases a fever with seizures. Talk with your doctor if you have concerns about this.

If you are very sick and have a high fever, you will probably need to wait until you are well before your receive this vaccine.

Influenza virus vaccine may not protect everyone who receives the vaccine. Also, this vaccine will not treat flu symptoms if you already have the virus.

The tip cap of the prefilled syringe for certain brands of the injection (Agriflu®, Fluarix®, Fluvirin®, Fluzone®, Fluzone® High-Dose) contains dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. Tell your doctor if you or your child have a latex allergy before you receive this vaccine.

It is important to tell your doctor if you become pregnant. Your doctor may want you to join a pregnancy registry for patients receiving Fluzone® Intradermal vaccine.

Make sure your doctor knows if you or your child are using a medicine or treatment that weakens your immune system, such as a steroid, radiation, or cancer treatment. This vaccine may not work as well if you are also using these medicines. Your doctor may still want you to get the vaccine because it can give you some protection.

Fluzone Side Effects

In 1976, a number of people who received the “swine flu” influenza vaccine developed Guillain-Barré syndrome (GBS), which is a disease that may cause paralysis. Most of these people were over 25 years of age. Although only 10 out of every one million people who received the vaccine actually developed GBS, this number was 6 times higher than would normally have been expected. Most of the people who got GBS recovered completely.

It is assumed that the “swine flu” virus included in the 1976 vaccine caused the problem, but this has not been proven. Since that time, studies have shown that the risk of acquiring GBS from an influenza vaccine is very low (one out of every million people).

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Cough

diarrhea

fever

headache

irritability

loss of appetite

muscle aches

redness of the eyes

sneezing

sore throat

stuffy or runny nose

vomiting

Less common

Body aches or pain

chills

difficulty with breathing

earache

ear congestion

loss of voice

shivering

swelling or puffiness of the face

tightness in the chest

unusual tiredness or weakness

Rare

Difficulty with swallowing

dizziness

fast heartbeat

hives

itching

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy breathing

puffiness or swelling of the eyelids or around the eyes, lips, or tongue

shortness of breath

skin rash

wheezing

Incidence not known

Agitation

back pain, sudden and severe

back, leg, or stomach pains

black, tarry stools

bleeding gums

bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, itching, lumps, numbness, scarring, soreness, stinging, tingling, ulceration, or warmth at the injection site

blindness

blistering, peeling, or loosening of the skin

blood in the urine or stools

blurred vision

bruising, inflammation, rash, redness, swelling, tenderness, or pain at the injection site

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

change in color vision

change in walking and balance

chest pain

clumsiness or unsteadiness

cold, clammy skin

coma

confusion

dark urine

discharge or excessive tearing

drowsiness

dryness of the throat

eye pain

fainting

fast, weak pulse

feeling hot

feeling of constant movement of self or surroundings

feeling unusually cold

general body swelling

general feeling of discomfort or illness

hallucinations

inability to move the arms and legs

increased sensitivity of the eyes to sunlight

irritation

joint pain, stiffness, or swelling

lack or loss of strength

large, flat, blue, or purplish patches in the skin

lightheadedness

mood or mental changes

muscle weakness, sudden and progressing

nausea

nerve pain

nosebleeds

pain, redness, soreness, swelling, tenderness, or warmth on the skin

painful knees and ankles

paleness of the skin

pinpoint red spots on the skin

redness of the face, neck, arms, and occasionally, upper chest

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

seizures

sensation of spinning

shakiness in the legs, arms, hands, or feet

sores, ulcers, or white spots in the mouth or on the lips

stabbing pain

stiff neck

stomach pain, soreness, or discomfort

sweating

swelling of the face, hands, or feet

swelling of the mouth or throat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

trouble with sleeping

troubled breathing or swallowing

unusual bleeding or bruising

voice changes

weakness of the muscles in your face

yellowing of the eyes or skin

Incidence not known

Sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Fluzone side effects (in more detail)

More Fluzone resources

Fluzone Side Effects (in more detail)
Fluzone Use in Pregnancy & Breastfeeding
Fluzone Drug Interactions
Fluzone Support Group
0 Reviews for Fluzone - Add your own review/rating

Fluzone Prescribing Information (FDA)

Fluzone MedFacts Consumer Leaflet (Wolters Kluwer)

Afluria Prescribing Information (FDA)

Afluria Consumer Overview

Afluria MedFacts Consumer Leaflet (Wolters Kluwer)

Agriflu Consumer Overview

Agriflu MedFacts Consumer Leaflet (Wolters Kluwer)

FluLaval MedFacts Consumer Leaflet (Wolters Kluwer)

FluLaval Consumer Overview

Fluarix Prescribing Information (FDA)

Fluarix MedFacts Consumer Leaflet (Wolters Kluwer)

Fluarix Consumer Overview

Flulaval Prescribing Information (FDA)

Fluvirin Prescribing Information (FDA)

Fluvirin MedFacts Consumer Leaflet (Wolters Kluwer)

Influenza Virus Vaccine Inactivated Monograph (AHFS DI)

Influenza Virus Vaccine Live Intranasal Monograph (AHFS DI)

Compare Fluzone with other medications

Influenza Prophylaxis

Sunday, July 22, 2012

Iburion

Iburion may be available in the countries listed below.

Ingredient matches for Iburion

Ibuprofen

Ibuprofen is reported as an ingredient of Iburion in the following countries:

Slovakia

International Drug Name Search

Saturday, July 21, 2012

Alacol DM

Generic Name: brompheniramine, dextromethorphan, and phenylephrine (brome fen IR a meen, dex troe metho OR fan, fen il EFF rin)

Brand Names: Alacol DM, Alahist DM, BP Allergy DM, BPM PE DM, Bromatan-DM, Bromtuss DM, BroveX PEB DM, Children's Cold & Cough DM, Cold & Cough Childrens, Dimaphen DM, Dimetapp Cold & Cough, Dimetapp DM Cold & Cough, DuraTan DM, Duravent DPB, Lohist-DM, Lortuss DM (obsolete), Tusdec-DM

What is Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Brompheniramine, dextromethorphan, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body. Brompheniramine, dextromethorphan, and phenylephrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

What should I discuss with my healthcare provider before taking Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking this medication, tell your doctor if you are allergic to brompheniramine, dextromethorphan, or phenylephrine, or if you have:

kidney disease;

liver disease;

diabetes;

glaucoma;

heart disease or high blood pressure;

diabetes;

a thyroid disorder;

a stomach ulcer or a stomach obstruction,

emphysema or chronic bronchitis; or

an enlarged prostate or urination problems.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Brompheniramine, dextromethorphan, and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cough-and-cold medications may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

Use this medication exactly as directed on the label or as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Take this medicine with food or milk if it upsets your stomach.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

Store the medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of this medication.

Avoid using other medicines that make you sleepy (such as sleeping pills, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine, dextromethorphan, and phenylephrine.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant.

Alacol DM (brompheniramine, dextromethorphan, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heartbeat;

confusion, hallucinations, unusual thoughts or behavior;

severe dizziness, anxiety, restless feeling, or nervousness;

increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

confusion, hallucinations, unusual thoughts or behavior;

slow, shallow breathing;

urinating less than usual or not at all;

easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

blurred vision;

dry mouth;

nausea, stomach pain, constipation;

mild loss of appetite, stomach upset;

warmth, tingling, or redness under your skin;

sleep problems (insomnia);

restless or excitability (especially in children);

skin rash or itching;

dizziness, drowsiness;

problems with memory or concentration; or

ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Alacol DM (brompheniramine, dextromethorphan, and phenylephrine)?

Before taking this medication, tell your doctor if you are using any of the following drugs:

an antidepressant;

a diuretic (water pill);

medication to treat irritable bowel syndrome;

celecoxib (Celebrex);

cinacalcet (Sensipar);

darifenacin (Enablex);

imatinib (Gleevec);

quinidine (Quinaglute, Quinidex);

ranolazine (Ranexa)

ritonavir (Norvir);

sibutramine (Meridia);

terbinafine (Lamisil);

medicines to treat high blood pressure;

aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol); or

a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others.

This list is not complete and there may be other drugs that can interact with brompheniramine, dextromethorphan, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Alacol DM resources

Alacol DM Side Effects (in more detail)
Alacol DM Use in Pregnancy & Breastfeeding
Alacol DM Drug Interactions
Alacol DM Support Group
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Alacol DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)

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Cough and Nasal Congestion

Where can I get more information?

Your pharmacist can provide more information about brompheniramine, dextromethorphan, and phenylephrine.

See also: Alacol DM side effects (in more detail)

Tuesday, July 31, 2012

Uses For pentetate zinc trisodium

Before Using pentetate zinc trisodium

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of pentetate zinc trisodium

Dosing

Precautions While Using pentetate zinc trisodium

pentetate zinc trisodium Side Effects

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Monday, July 30, 2012

What is argatroban?

What is the most important information I should know about argatroban?

What should I discuss with my health care provider before receiving argatroban?

How is argatroban given?

What happens if I miss a dose?

What happens if I overdose?

What should I avoid while receiving argatroban?

Argatroban side effects

Argatroban Dosing Information

What other drugs will affect argatroban?

More argatroban resources

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Where can I get more information?

Commonly used brand name(s)

Uses For ziconotide

Before Using ziconotide

Allergies

Pediatric

Geriatric

Pregnancy

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Proper Use of ziconotide

Precautions While Using ziconotide

ziconotide Side Effects

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Sunday, July 29, 2012

Read all of this leaflet carefully because it contains important information for you.

In this leaflet:

What Duphalac is and what it is used for

Before you take Duphalac

Do not take Duphalac if:

Pregnancy and breast-feeding

Important information about some of the ingredients of Duphalac

How to take Duphalac

Taking this medicine

Constipation

Hepatic encephalophathy

If you take more Duphalac than you should

If you forget to take Duphalac

Duphalac 200ml Side Effects

How to store Duphalac

Further information

What Duphalac contains

What Duphalac looks like and contents of the pack

Marketing Authorisation Holder and Manufacturer

Address

Contact Details

Thursday, July 26, 2012

Ciloxan Ointment is used for:

Do NOT use Ciloxan Ointment if:

Before using Ciloxan Ointment:

How to use Ciloxan Ointment:

Important safety information:

Possible side effects of Ciloxan Ointment:

If OVERDOSE is suspected:

General information:

More Ciloxan resources

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