DuraTan PE

Generic Name: chlorpheniramine, methscopolamine, and phenylephrine (KLOR fe NEER a meen, METH skoe POL a meen, FEN il EFF rin)

Brand Names: Aerohist Plus, Ah-Chew, Chlor-Mes, Dallergy (obsolete), Denaze, Duradryl, Durahist PE, DuraTan PE, Extendryl Chews, Histatab PH, Omnihist L.A., Ralix, Redur-PCM, Rescon MX

What is DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine is an anticholinergic (an-tye-kol-in-URJ-ik) that has a drying effect on the nasal passages.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, methscopolamine, and phenylephrine is used to treat runny nose, sneezing, itchy throat, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, methscopolamine, and phenylephrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Do not use this medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cold or allergy medicine before the MAO inhibitor has cleared from your body.

Before using this medicine, tell your doctor if you have heart disease, high blood pressure, or a heart rhythm disorder, circulation problems, glaucoma, diabetes, a thyroid disorder, kidney disease, or problems with urination.

Do not use any other over-the-counter cold, cough, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains chlorpheniramine or phenylephrine. Talk with your doctor if your symptoms do not improve after 5 days of treatment, or if you have a fever with a headache, cough, or skin rash.

What should I discuss with my health care provider before taking DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Do not take this medication if you are allergic to chlorpheniramine, methscopolamine, phenylephrine, or to other cold or allergy medicines, diet pills, stimulants, or ADHD medications. Do not use this medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cold or allergy medicine before the MAO inhibitor has cleared from your body.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  heart disease, high blood pressure, or a heart rhythm disorder;

  
  


• 
  

  a blood vessel disorder or circulation problems;

  
  


• 
  

  glaucoma;

  
  


• 
  

  diabetes;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  kidney disease;

  
  


• 
  

  asthma;

  
  


• 
  

  an enlarged prostate; or

  
  


• 
  

  problems with urination.

  
  

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication can decrease breast milk production, and also may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cold medicine is usually taken for only a short time until your symptoms clear up.

Take this medicine with a full glass of water. It is best to take this medicine with food.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. The suspension liquid form should be shaken well just before you measure a dose.

Do not crush, chew, break, or open an extended-release tablet unless your doctor tells you to. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time. However, some extended-release pills can be broken to split the dose. Ask your doctor or pharmacist if you have questions.

The chewable tablet must be chewed completely before you swallow it.

Tell your doctor if your symptoms do not improve after 5 days of treatment, or if you have a fever with a headache, cough, or skin rash.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include feeling restless or nervous, nausea, vomiting, extreme drowsiness, confusion, hallucinations, uneven heart rate, fainting, or seizure (convulsions).

What should I avoid while taking DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine or methscopolamine. Tell your doctor if you need to use any of these other medicines.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice.

Do not use any other over-the-counter cold, cough, or allergy medication without first asking your doctor or pharmacist. Chlorpheniramine and phenylephrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains chlorpheniramine or phenylephrine. Avoid drinking alcohol. It can add to drowsiness caused by an antihistamine.

DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, stomach pain, constipation;

  
  


• 
  

  mild loss of appetite;

  
  


• 
  

  dizziness, drowsiness, headache;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears;

  
  


• 
  

  restlessness or excitability (especially in children);

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  cold feeling in your hands or feet;

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect DuraTan PE (chlorpheniramine, methscopolamine, and phenylephrine)?

Before taking this medication, tell your doctor if you are using any other antihistamine or decongestant pills, liquids, or nasal sprays. Also tell your doctor if you are using any of the following drugs:

• 
  

  pramlintide (Symlin);

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Etrafon) or desipramine (Norpramin);

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


• 
  

  a diuretic (water pill), or medicines to treat high blood pressure, angina (chest pain), or other heart conditions;

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), risperidone (Risperdal), trazodone (Desyrel);

  
  


• 
  

  migraine headache medication such as sumatriptan (Imitrex), naratriptan (Amerge), zolmitriptan (Zomig), ergotamine (Ergostat, Ergomar); or

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with chlorpheniramine, methscopolamine, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More DuraTan PE resources

• DuraTan PE Side Effects (in more detail)
• DuraTan PE Use in Pregnancy & Breastfeeding
• DuraTan PE Drug Interactions
• DuraTan PE Support Group
• 0 Reviews for DuraTan PE - Add your own review/rating

• AH-Chew Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Aerohist Plus Sustained-Release and Long-Acting Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Allergy DN PE Prescribing Information (FDA)


• Dallergy Syrup Prescribing Information (FDA)


• Dehistine Prescribing Information (FDA)


• Duravent-DA Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Rescon Prescribing Information (FDA)

Compare DuraTan PE with other medications

• Nasal Congestion
• Rhinitis

Where can I get more information?

• Your pharmacist can provide more information about chlorpheniramine, methscopolamine, and phenylephrine.

See also: DuraTan PE side effects (in more detail)

Secrelux

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Secretin

Secretin hydrochloride (a derivative of Secretin) is reported as an ingredient of Secrelux in the following countries:

• Germany

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Herpesine

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Idoxuridine

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Clindamycin

Clindamycin dihydrogen phosphate (a derivative of Clindamycin) is reported as an ingredient of Clindamicina IBI in the following countries:

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Trimopan

Trimopan may be available in the countries listed below.

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Diphenhydramine

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Ceftriaxone

Ceftriaxone disodium salt (a derivative of Ceftriaxone) is reported as an ingredient of Ceftriazone Orion Pharma in the following countries:

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Kamostaal

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Camostat

Camostat mesilate (a derivative of Camostat) is reported as an ingredient of Kamostaal in the following countries:

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Meloxicam

Meloxicam is reported as an ingredient of Meloxicam Bexal in the following countries:

• Spain

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Doral

Generic Name: quazepam (Oral route)

KWAZ-e-pam

Commonly used brand name(s)

In the U.S.

• Doral

Available Dosage Forms:

• Tablet

Therapeutic Class: Hypnotic

Pharmacologic Class: Benzodiazepine, Long Acting

Uses For Doral

Quazepam is used to treat insomnia (trouble in sleeping). This medicine is for short-term (usually 7 to 10 days) use only. Quazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Before Using Doral

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of quazepam in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of quazepam in the elderly. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may an adjustment in the dose in patients receiving quazepam.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amobarbital


• Anileridine


• Aprobarbital


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlorzoxazone


• Codeine


• Dantrolene


• Ethchlorvynol


• Fentanyl


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Primidone


• Propoxyphene


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Thiopental


• Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• St John's Wort


• Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Breathing problems or lung disease or


• Depression—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Sleep apnea (temporary stopping of breathing during sleep)—Should not be used in patients with this condition.

Proper Use of Doral

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take quazepam just before going to bed, when you are ready to go to sleep. This medicine works very quickly to put you to sleep.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For insomnia (trouble in sleeping):
    
    • Adults—At first, 15 milligrams (mg) at bedtime. Your doctor may adjust your dose if needed.
    
    
    • Older adults—At first, 7.5 milligrams (mg) at bedtime. Your doctor may adjust your dose if needed.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Doral

It is very important that your doctor check your progress at regular visits to see if the medicine is working properly and to allow for changes in the dose.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Do not breastfeed while you are using this medicine.

If you develop any unusual and strange thoughts or behavior while you are taking quazepam, be sure to discuss it with your doctor. Some changes that have occurred in people taking this medicine are like those seen in people who drink alcohol and then act in a manner that is not normal. Other changes may be more unusual and extreme, such as confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

This medicine may cause sleep-related behaviors such as driving a car (sleep-driving), walking (sleep-walking), having sex, making phone calls, or preparing and eating food while asleep or not fully awake. If these reactions occur, tell your doctor right away.

Quazepam may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking this medicine and call your doctor right away if you have itching, hives, hoarseness, nausea or vomiting, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth or throat while you are using this medicine.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine.

This medicine may cause some people, especially older persons, to become drowsy or less alert than they are normally. Even though quazepam is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, or are not alert or able to see well.

Do not stop taking it without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.

If your condition does not improve within 7 to 10 days, or if it becomes worse, check with your doctor.

Doral Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Drowsiness

Less common

• Dizziness

Rare

• Anxiety


• dry mouth


• hyperventilation


• increased muscle spasm


• irregular heartbeats


• irritability


• nervousness


• nightmares


• restlessness


• shaking


• shortness of breath


• trouble in sleeping


• unusual excitement, nervousness, restlessness, or irritability

Incidence not known

• Abdominal or stomach pain


• changes in patterns and rhythms of speech


• chills


• clay-colored stools


• dark urine


• decrease in frequency of urination


• decrease in urine volume


• difficulty in passing urine (dribbling)


• fever


• headache


• inability to move eyes


• increased blinking or spasms of the eyelid


• itching


• loss of appetite


• loss of bladder control


• nausea


• painful urination


• rash


• seizures


• shakiness in the legs, arms, hands, or feet


• sleeplessness


• slurred speech


• sticking out of the tongue


• trembling or shaking of the hands or feet


• trouble in breathing, speaking, or swallowing


• unable to sleep


• uncontrolled twisting movements of the neck, trunk, arms, or legs


• unpleasant breath odor


• unusual facial expressions


• unusual tiredness or weakness


• vomiting of blood


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Change in consciousness


• loss of consciousness


• mood or mental changes


• sleepiness or unusual drowsiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Acid or sour stomach


• belching


• heartburn


• indigestion


• stomach discomfort, upset, or pain

Incidence not known

• Decreased interest in sexual intercourse


• inability to have or keep an erection


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• loss in sexual ability, desire, drive, or performance


• menstrual changes


• sweating


• vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Doral side effects (in more detail)

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More Doral resources

• Doral Side Effects (in more detail)
• Doral Use in Pregnancy & Breastfeeding
• Drug Images
• Doral Drug Interactions
• Doral Support Group
• 1 Review for Doral - Add your own review/rating

• Doral MedFacts Consumer Leaflet (Wolters Kluwer)


• Doral Concise Consumer Information (Cerner Multum)


• Quazepam Professional Patient Advice (Wolters Kluwer)

Compare Doral with other medications

• Insomnia

Fosfocine

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Fosfomycin

Fosfomycin is reported as an ingredient of Fosfocine in the following countries:

• Tunisia

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• France

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Ginedazol

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Miconazole

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• Peru

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• Peru

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Desomedin

Desomedin may be available in the countries listed below.

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Hexamidine diisetionate (a derivative of Hexamidine) is reported as an ingredient of Desomedin in the following countries:

• Switzerland

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Clindamycin is reported as an ingredient of Klindamicin in the following countries:

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Deferasirox

Pronunciation: dee-FER-a-sir-ox
Generic Name: Deferasirox
Brand Name: Exjade

Deferasirox may cause severe and sometimes fatal kidney problems, liver problems, or stomach or bowel bleeding. The risk may be greater in patients who have low blood platelet counts or who already have kidney or liver problems. It may also be greater in the elderly and in patients who have certain blood or bone marrow problems (high-risk myelodysplastic syndromes [MDS]). Lab tests, including kidney and liver function, may be performed while you use Deferasirox to check for side effects. Be sure to keep all doctor and lab appointments.

Tell your doctor if you develop symptoms of kidney problems (eg, decreased urination) or liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite). Tell your doctor if you develop symptoms of stomach or bowel bleeding (eg, stomach pain; black, tarry stools; vomit that looks like coffee grounds).

Deferasirox is used for:

Treating high levels of iron in the blood caused by blood transfusions.

Deferasirox is an iron-chelating agent. It works by binding to the extra iron in the blood and removing it from the body.

Do NOT use Deferasirox if:

• you are allergic to any ingredient in Deferasirox


• you have severe kidney or liver problems, or very low blood platelet levels


• you have certain blood or bone marrow problems (high-risk MDS) or advanced cancer

Contact your doctor or health care provider right away if any of these apply to you.

Before using Deferasirox:

Some medical conditions may interact with Deferasirox. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney problems (eg, kidney failure), liver problems (eg, cirrhosis), or stomach or bowel problems (eg, bleeding, ulcers)


• if you have cancer, blood or bone marrow problems, low blood platelets, vision or eye problems, hearing problems, or an infection


• if you are dehydrated


• if you are 65 years or older and have MDS

Some MEDICINES MAY INTERACT with Deferasirox. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), oral bisphosphonates (eg, alendronate), corticosteroids (eg, prednisone), or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach ulcers or bleeding may be increased


• Other iron-chelating medicines (eg, deferoxamine) because they may increase the risk of Deferasirox's side effects


• Cholestyramine, fosphenytoin, phenobarbital, phenytoin, rifampin, or ritonavir because they may decrease Deferasirox's effectiveness


• Cyclobenzaprine, fluvoxamine, haloperidol, imipramine, mexiletine, olanzapine, paclitaxel, repaglinide, theophyllines (eg, aminophylline), tizanidine, zileuton, or zolmitriptan because the risk of their side effects may be increased by Deferasirox


• Cyclosporine, hormonal contraceptives (eg, birth control), or simvastatin because their effectiveness may be decreased by Deferasirox


• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, NSAIDs [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney

This may not be a complete list of all interactions that may occur. Ask your health care provider if Deferasirox may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Deferasirox:

Use Deferasirox as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Deferasirox by mouth on an empty stomach at least 30 minutes before eating. Take it at the same time each day.


• Do not chew or swallow the tablet whole. You must mix Deferasirox with water, orange juice, or apple juice before you take it. Ask your doctor or pharmacist how much fluid you should use to mix your dose of Deferasirox.


• To mix Deferasirox, place the tablet in the correct amount of water, orange juice, or apple juice. Stir well until the tablet has completely dissolved, then immediately drink all of the liquid. Rinse the container with an additional small amount of water, orange juice, or apple juice and drink the contents to ensure the entire dose is taken.


• Take Deferasirox on a regular schedule to get the most benefit from it.


• Do not take an antacid that has aluminum in it at the same time you take Deferasirox. If you take antacids that contain aluminum, ask your doctor or pharmacist how to take them with Deferasirox.


• If you miss a dose of Deferasirox, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Deferasirox.

Important safety information:

• Deferasirox may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Deferasirox with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.


• Serious and sometimes fatal stomach ulcers or bleeding have been reported with the use of Deferasirox. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Deferasirox. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Lab tests, including liver and kidney function, blood ferritin and iron levels, vision, hearing, and complete blood cell counts, may be performed while you take Deferasirox. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Deferasirox with caution in the ELDERLY; they may be more sensitive to its effects, especially kidney problems, liver problems, and stomach or bowel bleeding.


• Deferasirox should be used with extreme caution in CHILDREN younger than 2 years; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Deferasirox while you are pregnant. It is not known if Deferasirox is found in breast milk. Do not breast-feed while taking Deferasirox.

Possible side effects of Deferasirox:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody, black, or tarry stools; change in the amount of urine produced; decreased hearing, hearing loss, or other hearing problems; symptoms of infection (eg, fever, chills, persistent sore throat or cough); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite); unusual bruising or bleeding; unusual tiredness or fatigue; vision changes (eg, blurred or cloudy vision, decreased vision); vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Deferasirox side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea and diarrhea.

Proper storage of Deferasirox:

Store Deferasirox at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Deferasirox out of the reach of children and away from pets.

General information:

• If you have any questions about Deferasirox, please talk with your doctor, pharmacist, or other health care provider.


• Deferasirox is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Deferasirox. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Deferasirox resources

• Deferasirox Side Effects (in more detail)
• Deferasirox Use in Pregnancy & Breastfeeding
• Deferasirox Drug Interactions
• Deferasirox Support Group
• 0 Reviews for Deferasirox - Add your own review/rating

• Deferasirox Professional Patient Advice (Wolters Kluwer)


• Deferasirox Monograph (AHFS DI)


• deferasirox Advanced Consumer (Micromedex) - Includes Dosage Information


• Exjade Prescribing Information (FDA)


• Exjade Consumer Overview

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Tiaprid-biomo

Tiaprid-biomo may be available in the countries listed below.

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Tiapride

Tiapride hydrochloride (a derivative of Tiapride) is reported as an ingredient of Tiaprid-biomo in the following countries:

• Germany

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Desonide Lotion

Desonide Lotion 0.05%

Rx Only

For Dermatologic Use Only

Not for Ophthalmic Use

Desonide Lotion Description

Desonide Lotion 0.05% contains desonide (Pregna-1,4-diene-3,20-dione,11,21-dihydroxy-16,17 -[(1-melhylethylidene)bis(oxy)]-,(11β, 16α)- a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and anti-pruritic agents.

Chemically, desonide is C24H3206. It has the following structural formula:

Desonide has the molecular weight of 416.51. It is a white to off white odorless powder which is soluble in methanol and practically insoluble in water. Each gram of Desonide Lotion contains 0.5 mg of desonide in a base of cetyl alcohol, edetate sodium, glyceryl stearate SE, light mineral oil, methylparaben, propylene glycol, propylparaben, purified water, sodium lauryl sulfate, sorbitan monostearate, and stearyl alcohol. May contain citric acid and/or sodium hydroxide for pH adjustment.

Desonide Lotion - Clinical Pharmacology

Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption.

Studies performed with Desonide Lotion indicate that it is in the low to medium range of potency as compared with other topical corticosteroids.

INDICATION AND USAGE

Desonide Lotion is low to medium potency corticosteroids indicated for the relief of the Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

Contraindications

Desonide Lotion is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

Precautions

General: Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment. Patients applying a topical steroid to a large surface area or to areas under occlusion should be evaluated periodically for evidence of HPA axis suppression. This may be done by using the ACTH stimulation, A.M. plasma cortisol, and urinary free cortisol tests. Patients receiving superpotent corticosteroids should not be treated for more than 2 weeks at a time and only small areas should be treated at any one time due to the increased risk of HPA axis suppression.

If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids. Infrequently, signs and symptoms of glucocorticosteroid insufficiency may occur requiring supplemental systemic corticosteroids. For information on systemic supplementation, see prescribing information for those products.

Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their larger skin surface to body mass ratios. (See   PRECAUTIONS: Pediatric Use).

If irritation develops, Desonide Lotion should be discontinued and appropriate therapy instituted. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing failure to heal rather than noting a clinical exacerbation as with most topical products not containing corticosteroids. Such an observation should be corroborated with appropriate diagnostic patch testing.

If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. If a favorable response does not occur promptly, use of Desonide Lotion should be discontinued until the infection has been adequately controlled.

Information for patients

Patients using topical corticosteroids should receive the following information and Instructions:

1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.

2. This medication should not be used for any disorder other than that for which it was prescribed.

3. The treated skin area should not be bandaged or otherwise covered or wrapped so as to be occlusive unless directed by the physician.

4. Patients should report to their physician any signs of local adverse reactions.

Laboratory tests

The following tests may be helpful in evaluating patients for HPA axis suppression:

ACTH stimulation test

A.M. plasma cortisol test

Urinary free cortisol test

Carcinogenesis, mutagenesis, and impairment or fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on reproduction with the use of Desonide Lotion.

Pregnancy

Teratogenic effects: Pregnancy category C:

Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relativity low dosage levels. Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. Animal reproduction studies have not been conducted with Desonide Lotion. It is also not known whether Desonide Lotion can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Desonide Lotion should be given to a pregnant woman only if clearly needed.

Nursing mothers

Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk. Because many drugs are excreted in human milk, caution should be exercised when Desonide Lotion is administered to a nursing woman.

Pediatric use

Safety and effectiveness in pediatric patients have not been established. Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids. They are therefore also at greater risk of glucocorticosteroid insufficiency after withdrawal of treatment and of Cushing's syndrome while on treatment. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children.

HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Adverse Reactions

In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%. Irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.

The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.

Overdosage

Topically applied Desonide Lotion can be absorbed in sufficient amounts to produce systemic effects (see  PRECAUTIONS)

Desonide Lotion Dosage and Administration

Desonide Lotion should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. SHAKE LOTION WELL BEFORE USING.

As with other corticosteroids, therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.

Desonide Lotion should not be used with occlusive dressings.

How is Desonide Lotion Supplied

Desonide Lotion 0.05% is supplied as follows:

2 fl oz bottle - NDC 0472-0803-02

4 fl oz bottle - NDC 0472-0803-04

Storage Conditions

Store between 2° and 30°C (36° and 86°F).

Distributed by:

Actavis Mid Atlantic LLC

1877 Kawai Road

Lincolnton, NC 28092 USA

Manufactured by

DPT Laboratories, Ltd.

San Antonio, Texas 78215 USA

325097-0209     Revised: February 2009

Desonide Lotion 0.05% 4 fl oz - Front Label

Desonide Lotion 0.05% 4 fl oz - Back Label

Desonide Lotion 0.05% 2 fl oz - Front Label

Desonide Lotion 0.05% 2 fl oz - Back Label

DESONIDE  LOTION 0.05% Desonide Lotion 0.05%  lotion

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0472-0803 Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength DESONIDE (DESONIDE) DESONIDE 0.5 mg  in 1 g

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0472-0803-02 57.1 g In 1 BOTTLE, PLASTIC None 2 0472-0803-04 114.1 g In 1 BOTTLE, PLASTIC None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA072354	05/28/2009

Labeler - Actavis Mid Atlantic LLC, Lincolnton, NC 28092 (605461925)

Revised: 06/2009Actavis Mid Atlantic LLC, Lincolnton, NC 28092

More Desonide Lotion resources

• Desonide Lotion Side Effects (in more detail)
• Desonide Lotion Use in Pregnancy & Breastfeeding
• Desonide Lotion Drug Interactions
• Desonide Lotion Support Group
• 17 Reviews for Desonide - Add your own review/rating

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Hyaluronic Acid is reported as an ingredient of Suprahyal in the following countries:

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Hyaluronic Acid sodium salt (a derivative of Hyaluronic Acid) is reported as an ingredient of Suprahyal in the following countries:

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Ostan

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Aluminium Acetotartrate is reported as an ingredient of Euceta in the following countries:

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Mebendazole

Mebendazole is reported as an ingredient of Mebendazol Denver in the following countries:

• Argentina

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Tertiary Syphilis Medications

Definition of Tertiary Syphilis: Tertiary syphilis is a late phase of the sexually transmitted disease syphilis, caused by the spirochete

Drugs associated with Tertiary Syphilis

The following drugs and medications are in some way related to, or used in the treatment of Tertiary Syphilis. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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Ala-Tet

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Micotop

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Miconazole

Miconazole is reported as an ingredient of Micotop in the following countries:

• Romania

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Sera med Professional Tremazol

Sera med Professional Tremazol may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

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Praziquantel is reported as an ingredient of Sera med Professional Tremazol in the following countries:

• Switzerland

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Citalopram Genericon

Citalopram Genericon may be available in the countries listed below.

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Citalopram

Citalopram hydrobromide (a derivative of Citalopram) is reported as an ingredient of Citalopram Genericon in the following countries:

• Austria

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Dynabac

Generic Name: dirithromycin (dir ith roe MYE sin)

Brand Names: Dynabac

What is Dynabac (dirithromycin)?

Dirithromycin is in a class of drugs called macrolide antibiotics. Dirithromycin fights bacteria in your body.

Dirithromycin is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and skin infections.

Dirithromycin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Dynabac (dirithromycin)?

Take all of the dirithromycin that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Take dirithromycin with food or within 1 hour of eating to increase the absorption of the drug by your body. Do not break, crush, or chew the tablets. Swallow them whole.

Who should not take Dynabac (dirithromycin)?

Before taking dirithromycin, tell your doctor if you have liver disease. You may not be able to take dirithromycin, or you may require a lower dose or special monitoring during therapy.

Dirithromycin is in the FDA pregnancy category C. This means that it is not known whether dirithromycin will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether dirithromycin passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. Dirithromycin has not been approved for use in children younger than 12 years of age.

How should I take Dynabac (dirithromycin)?

Take dirithromycin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water. Take dirithromycin with food or milk to increase the absorption of the drug into your body. Do not break, crush, or chew the tablets. Swallow them whole. Take all of the dirithromycin that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a dirithromycin overdose include nausea, vomiting, diarrhea, and abdominal discomfort.

What should I avoid while taking Dynabac (dirithromycin)?

Avoid prolonged exposure to sunlight. Dirithromycin may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Dynabac (dirithromycin) side effects

If you experience any of the following serious side effects, stop taking dirithromycin and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or

  
  


• 
  

  liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).

  
  

Other, less serious side effects may be more likely to occur. Continue to take dirithromycin and talk to your doctor if you experience

• 
  

  nausea, vomiting, diarrhea, or abdominal pain;

  
  


• 
  

  dizziness, fatigue, or headache;

  
  


• 
  

  vaginal yeast infection; or

  
  


• 
  

  a rash.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Dynabac (dirithromycin)?

Other drugs in the same class as dirithromycin have caused dangerous side effects when taken with terfenadine (Seldane). Although dirithromycin has not caused the same reaction, it should be used cautiously if at all while you are taking terfenadine (Seldane).

Before taking this medication, tell your doctor if you are taking any of the following drugs:

• 
  

  seizure medications such as carbamazepine (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote, Depakene) may or may not be affected. Since these drugs are so important, your doctor may want to perform some special blood-monitoring tests.

  
  


• 
  

  anticoagulants (blood thinners) such as warfarin (Coumadin). These medications may have an increased effect, which could lead to bleeding. Your doctor may want to monitor your blood clotting.

  
  


• 
  

  heart medications for irregular heartbeats, such as digoxin (Lanoxin). These drugs may also have an increased effect. Your doctor may want to monitor your blood levels more closely.

  
  


• 
  

  other antibiotics. Do not use other antibiotics unless they are prescribed by your doctor.

  
  

Drugs other than those listed here may also interact with dirithromycin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Dynabac resources

• Dynabac Side Effects (in more detail)
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• Dynabac Drug Interactions
• Dynabac Support Group
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Where can I get more information?

• Your pharmacist has additional information about dirithromycin written for health professionals that you may read.

What does my medication look like?

Dirithromycin is available with a prescription under the brand name Dynabac. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• 
  

  Dynabac 250 mg--elliptical, white, enteric-coated tablets

  
  

See also: Dynabac side effects (in more detail)

Sympramol

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Opipramol

Opipramol dihydrochloride (a derivative of Opipramol) is reported as an ingredient of Sympramol in the following countries:

• Poland

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Zidoval

Zidoval may be available in the countries listed below.

UK matches:

• Zidoval (SPC)

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Metronidazole

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• Australia


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Glossary

SPC	Summary of Product Characteristics (UK)

Click for further information on drug naming conventions and International Nonproprietary Names.

Lethanal

Lethanal may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

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Pentobarbital

Pentobarbital sodium salt (a derivative of Pentobarbital) is reported as an ingredient of Lethanal in the following countries:

• Netherlands

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Methylphenidate

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Ditropan Syrup

Pronunciation: OX-i-BUE-ti-nin
Generic Name: Oxybutynin
Brand Name: Generic only. No brands available.

Ditropan Syrup is used for:

Relieving symptoms of bladder problems (urinary urgency, frequency, or leakage; loss of bladder control; and painful urination) in certain patients. It may also be used for other conditions as determined by your doctor.

Ditropan Syrup is an anticholinergic. It works by relaxing muscles in the bladder.

Do NOT use Ditropan Syrup if:

• you are allergic to any ingredient in Ditropan Syrup


• you have bladder blockage or are unable to urinate


• you have certain stomach or bowel problems (eg, blockage, decreased muscle movement)


• you have uncontrolled narrow-angle glaucoma


• you are taking a solid oral potassium product (eg, tablet)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ditropan Syrup:

Some medical conditions may interact with Ditropan Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have trouble urinating or very poor health


• if you have a history of heart problems (eg, heart failure, fast or irregular heartbeat), high blood pressure, nervous system problems, liver or kidney problems, myasthenia gravis, an enlarged prostate, an overactive thyroid, esophagus problems (eg, reflux disease, inflammation, narrowing), stomach or bowel problems (eg, colitis, inflammation, constipation), or a hiatal hernia


• if you have a history of glaucoma or increased pressure in the eyes, or if you are at risk of glaucoma (eg, family history of glaucoma)

Some MEDICINES MAY INTERACT with Ditropan Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Bisphosphonates (eg, alendronate) because the risk of irritation of the esophagus may be increased


• Other anticholinergic medicines (eg, scopolamine), azole antifungals (eg, ketoconazole), or macrolide antibiotics (eg, erythromycin) because they may increase the risk of Ditropan Syrup's side effects


• Solid oral potassium products (eg, tablets) because the risk of stomach or bowel irritation may be increased by Ditropan Syrup


• Phenothiazines (eg, chlorpromazine) because their effectiveness may be decreased by Ditropan Syrup and they may increase the risk of Ditropan Syrup's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ditropan Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ditropan Syrup:

Use Ditropan Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ditropan Syrup by mouth with or without food.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Take Ditropan Syrup on a regular schedule to get the most benefit from it. Taking Ditropan Syrup at the same time each day will help you remember to take it.


• Continue to take Ditropan Syrup even if you feel well. Do not miss any doses.


• If you miss a dose of Ditropan Syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ditropan Syrup.

Important safety information:

• Ditropan Syrup may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ditropan Syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Ditropan Syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Ditropan Syrup may cause decreased sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Contact your doctor if you have been exposed to high temperatures and you develop fever; flushing; hot, dry skin; severe or persistent headache; dizziness; sudden fatigue; fast heartbeat; seizures; or fainting.


• Ditropan Syrup may cause dry mouth. To help relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. Ask your doctor or pharmacist if you have any questions.


• Ditropan Syrup may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.


• Use Ditropan Syrup with caution in the ELDERLY; they may be more sensitive to its effects.


• Ditropan Syrup should be used with extreme caution in CHILDREN younger than 5 years; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Ditropan Syrup can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ditropan Syrup while you are pregnant. It is not known if Ditropan Syrup is found in breast milk. If you are or will be breast-feeding while you use Ditropan Syrup, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ditropan Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; diarrhea; dizziness; drowsiness; dry eyes, nose, skin, or mouth; headache; indigestion; nausea; stomach pain; taste changes; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); confusion; difficult or painful urination; fast or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation); seizures; swelling of the hands, ankles, or feet; vision problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ditropan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; delirium; fever; flushing; hallucinations; inability to urinate; irregular heartbeat; paralysis; seizures; severe or persistent dizziness or headache; tremor; trouble breathing; vomiting.

Proper storage of Ditropan Syrup:

Store Ditropan Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tight container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ditropan Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Ditropan Syrup, please talk with your doctor, pharmacist, or other health care provider.


• Ditropan Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ditropan Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ditropan resources

• Ditropan Side Effects (in more detail)
• Ditropan Use in Pregnancy & Breastfeeding
• Drug Images
• Ditropan Drug Interactions
• Ditropan Support Group
• 9 Reviews for Ditropan - Add your own review/rating

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